tert-Butyl-(2-{(4S,6R)-6-[(1E,3E)-(R)-8-(4-methoxy-benzyloxy)-nona-1,3-dienyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethoxy)-diphenyl-silane

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Chemical Name:tert-Butyl-(2-{(4S,6R)-6-[(1E,3E)-(R)-8-(4-methoxy-benzyloxy)-nona-1,3-dienyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethoxy)-diphenyl-silane
CAS No.:863921-92-0
Molecular Formula:C₄₁H₅₆O₅Si
Molecular Weight:656.978
Hs Code.:

Synonyms:tert-Butyl-(2-{(4S,6R)-6-[(1E,3E)-(R)-8-(4-methoxy-benzyloxy)-nona-1,3-dienyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethoxy)-diphenyl-silane

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Chemical Property of tert-Butyl-(2-{(4S,6R)-6-[(1E,3E)-(R)-8-(4-methoxy-benzyloxy)-nona-1,3-dienyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethoxy)-diphenyl-silane

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Technology Process of tert-Butyl-(2-{(4S,6R)-6-[(1E,3E)-(R)-8-(4-methoxy-benzyloxy)-nona-1,3-dienyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethoxy)-diphenyl-silane

There total 10 articles about tert-Butyl-(2-{(4S,6R)-6-[(1E,3E)-(R)-8-(4-methoxy-benzyloxy)-nona-1,3-dienyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethoxy)-diphenyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 863921-91-9
(2-{(4S,6R)-6-[(1E,3E)-(R)-6-Benzenesulfonyl-8-(4-methoxy-benzyloxy)-nona-1,3-dienyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethoxy)-tert-butyl-diphenyl-silane

: 863921-92-0
tert-Butyl-(2-{(4S,6R)-6-[(1E,3E)-(R)-8-(4-methoxy-benzyloxy)-nona-1,3-dienyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethoxy)-diphenyl-silane

Guidance literature:: With disodium hydrogenphosphate; sodium amalgam; In methanol; at 0 ℃;
DOI:10.1246/cl.2005.906

Reference yield:

: 863921-90-8
{2-[(4S,6R)-6-((1E,3E)-5-Bromo-penta-1,3-dienyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-ethoxy}-tert-butyl-diphenyl-silane

: 863921-92-0
tert-Butyl-(2-{(4S,6R)-6-[(1E,3E)-(R)-8-(4-methoxy-benzyloxy)-nona-1,3-dienyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethoxy)-diphenyl-silane

Guidance literature:: Multi-step reaction with 2 steps

1.1: BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: 93 percent / tetrahydrofuran; hexane / -78 - -40 °C

2.1: 66 percent / Na₂HPO₄; Na/Hg / methanol / 5 h / 0 - 20 °C

With disodium hydrogenphosphate; sodium amalgam; n-butyllithium; In tetrahydrofuran; methanol; hexane;
DOI:10.1016/j.tet.2005.07.106

Reference yield:

: (2E,4E)-5-{(4R,6S)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-penta-2,4-dienoic acid ethyl ester

: 863921-92-0
tert-Butyl-(2-{(4S,6R)-6-[(1E,3E)-(R)-8-(4-methoxy-benzyloxy)-nona-1,3-dienyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethoxy)-diphenyl-silane

Guidance literature:: Multi-step reaction with 4 steps

1.1: 91 percent / DIBAL-H / CH₂Cl₂; hexane / 0.5 h / -78 °C

2.1: 95 percent / triphenylphosphane; NBS / CH₂Cl₂ / 0.5 h / -78 °C

3.1: BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

3.2: 93 percent / tetrahydrofuran; hexane / -78 - -40 °C

4.1: 66 percent / Na₂HPO₄; Na/Hg / methanol / 5 h / 0 - 20 °C

With disodium hydrogenphosphate; sodium amalgam; N-Bromosuccinimide; n-butyllithium; diisobutylaluminium hydride; triphenylphosphine; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1016/j.tet.2005.07.106