(3S,4R)-4-((1R,2S,3S)-3-Azido-2-hydroxy-cyclohexyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-azetidin-2-one

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Chemical Name:(3S,4R)-4-((1R,2S,3S)-3-Azido-2-hydroxy-cyclohexyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-azetidin-2-one
CAS No.:181228-86-4
Molecular Formula:C₁₇H₃₂N₄O₃Si
Molecular Weight:368.552
Hs Code.:

Synonyms:(3S,4R)-4-((1R,2S,3S)-3-Azido-2-hydroxy-cyclohexyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-azetidin-2-one

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Chemical Property of (3S,4R)-4-((1R,2S,3S)-3-Azido-2-hydroxy-cyclohexyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-azetidin-2-one

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Technology Process of (3S,4R)-4-((1R,2S,3S)-3-Azido-2-hydroxy-cyclohexyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-azetidin-2-one

There total 1 articles about (3S,4R)-4-((1R,2S,3S)-3-Azido-2-hydroxy-cyclohexyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 135297-04-0
(3S,4R)-4-[(1R,2S,3R)-2,3-epoxycyclohexyl]-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one

: 181228-86-4
(3S,4R)-4-((1R,2S,3S)-3-Azido-2-hydroxy-cyclohexyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-azetidin-2-one

Guidance literature:: With sodium azide; ammonium chloride; In ethanol; water; for 20h; Heating;
DOI:10.1016/0960-894X(96)00292-2

Reference yield: 70.0%

: 181228-86-4
(3S,4R)-4-((1R,2S,3S)-3-Azido-2-hydroxy-cyclohexyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-azetidin-2-one

: 135297-25-5
(3S,4R)-4-((1R,3S)-3-Azido-2-oxo-cyclohexyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-azetidin-2-one

Guidance literature:: With pyridinium chlorochromate; In dichloromethane; at 22 ℃; for 18h;
DOI:10.1016/0960-894X(96)00292-2

Reference yield:

: 181228-86-4
(3S,4R)-4-((1R,2S,3S)-3-Azido-2-hydroxy-cyclohexyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-azetidin-2-one

: (3S,4R)-4-((1R,3S)-3-Amino-2-oxo-cyclohexyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-azetidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / PCC / CH₂Cl₂ / 18 h / 22 °C

2: H₂ / Pd/C / ethyl acetate / 5 h / 22 °C / 2280 Torr

With hydrogen; pyridinium chlorochromate; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1016/0960-894X(96)00292-2