ethyl 2-((2-[(2R)-2-((1E,3S)-4-[3-(6-methyl-1,3-benzoxazol-2-yl)phenyl]-3-hydroxy-1-buten-1-yl)-5-oxo-1-pyrrolidinyl]ethyl)thio)-1,3-thiazole-4-carboxylate

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Chemical Name:ethyl 2-((2-[(2R)-2-((1E,3S)-4-[3-(6-methyl-1,3-benzoxazol-2-yl)phenyl]-3-hydroxy-1-buten-1-yl)-5-oxo-1-pyrrolidinyl]ethyl)thio)-1,3-thiazole-4-carboxylate
CAS No.:1380347-54-5
Molecular Formula:C₃₀H₃₁N₃O₅S₂
Molecular Weight:577.725
Hs Code.:

Synonyms:ethyl 2-((2-[(2R)-2-((1E,3S)-4-[3-(6-methyl-1,3-benzoxazol-2-yl)phenyl]-3-hydroxy-1-buten-1-yl)-5-oxo-1-pyrrolidinyl]ethyl)thio)-1,3-thiazole-4-carboxylate

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Chemical Property of ethyl 2-((2-[(2R)-2-((1E,3S)-4-[3-(6-methyl-1,3-benzoxazol-2-yl)phenyl]-3-hydroxy-1-buten-1-yl)-5-oxo-1-pyrrolidinyl]ethyl)thio)-1,3-thiazole-4-carboxylate

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Technology Process of ethyl 2-((2-[(2R)-2-((1E,3S)-4-[3-(6-methyl-1,3-benzoxazol-2-yl)phenyl]-3-hydroxy-1-buten-1-yl)-5-oxo-1-pyrrolidinyl]ethyl)thio)-1,3-thiazole-4-carboxylate

There total 11 articles about ethyl 2-((2-[(2R)-2-((1E,3S)-4-[3-(6-methyl-1,3-benzoxazol-2-yl)phenyl]-3-hydroxy-1-buten-1-yl)-5-oxo-1-pyrrolidinyl]ethyl)thio)-1,3-thiazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₂H₃₅N₃O₆S₂

: 1380347-54-5
ethyl 2-((2-[(2R)-2-((1E,3S)-4-[3-(6-methyl-1,3-benzoxazol-2-yl)phenyl]-3-hydroxy-1-buten-1-yl)-5-oxo-1-pyrrolidinyl]ethyl)thio)-1,3-thiazole-4-carboxylate

Guidance literature:: With sodium tris(acetoxy)borohydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 - 20 ℃; for 15h; Inert atmosphere;
DOI:10.1016/j.bmc.2012.04.008

Reference yield:

: C₂₉H₃₄N₂O₆

: 1380347-54-5
ethyl 2-((2-[(2R)-2-((1E,3S)-4-[3-(6-methyl-1,3-benzoxazol-2-yl)phenyl]-3-hydroxy-1-buten-1-yl)-5-oxo-1-pyrrolidinyl]ethyl)thio)-1,3-thiazole-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: borane-THF; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran; toluene / 1.08 h / 20 °C / Inert atmosphere

1.2: 0.08 h / 20 °C / Inert atmosphere

2.1: hydrogenchloride / 1,4-dioxane; ethanol / 6 h / 20 °C / Inert atmosphere

3.1: tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 50 °C / Inert atmosphere

4.1: sodium tris(acetoxy)borohydride / tetrahydrofuran; N,N-dimethyl-formamide / 15 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; borane-THF; sodium tris(acetoxy)borohydride; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2012.04.008

Reference yield:

: C₂₄H₂₈N₂O₄*ClH

: 1380347-54-5
ethyl 2-((2-[(2R)-2-((1E,3S)-4-[3-(6-methyl-1,3-benzoxazol-2-yl)phenyl]-3-hydroxy-1-buten-1-yl)-5-oxo-1-pyrrolidinyl]ethyl)thio)-1,3-thiazole-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 50 °C / Inert atmosphere

2: sodium tris(acetoxy)borohydride / tetrahydrofuran; N,N-dimethyl-formamide / 15 h / 0 - 20 °C / Inert atmosphere

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.04.008