N₁-[3-({[3fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]-L-serinamide hydrochloride

Base Information

• Chemical Name: N₁-[3-({[3fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]-L-serinamide hydrochloride
• CAS No.: 953392-21-7
• Molecular Formula: C₂₁H₂₂FN₃O₆S*ClH
• Molecular Weight: 499.948

Synonyms:N₁-[3-({[3fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]-L-serinamide hydrochloride

Chemical Property of N₁-[3-({[3fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]-L-serinamide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of N₁-[3-({[3fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]-L-serinamide hydrochloride

There total 6 articles about N₁-[3-({[3fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]-L-serinamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1-dimethylethyl [(1S)-2-{[3-({[3-fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]amino}-1-(hydroxymethyl)-2-oxoethyl]carbamate (953391-70-3) → N1-[3-({[3fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]-L-serinamide hydrochloride (953392-21-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 1h;

Reference yield:

4-bromo-3-fluoro-N-[2-(methyloxy)-5-nitrophenyl]benzenesulfonamide (953391-61-2) → N1-[3-({[3fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]-L-serinamide hydrochloride (953392-21-7)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 6 h / Heating / reflux

2: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 18 - 24 h

3: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 3 h / 20 °C

4: hydrogenchloride / 1,4-dioxane / 1 h

With hydrogenchloride; hydrogen; sodium carbonate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; HATU; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;

Reference yield:

4-bromo-3-fluorobenzene-1-sulfonyl chloride (351003-51-5) → N1-[3-({[3fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]-L-serinamide hydrochloride (953392-21-7)

Guidance literature:

Multi-step reaction with 5 steps

1: pyridine / dichloromethane / 0.5 - 2 h / 0 - 20 °C

2: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 6 h / Heating / reflux

3: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 18 - 24 h

4: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 3 h / 20 °C

5: hydrogenchloride / 1,4-dioxane / 1 h

With pyridine; hydrogenchloride; hydrogen; sodium carbonate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; HATU; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;

upstream raw materials:

1,1-dimethylethyl [(1S)-2-{[3-({[3-fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]amino}-1-(hydroxymethyl)-2-oxoethyl]carbamate

4-bromo-3-fluorobenzene-1-sulfonyl chloride

4-bromo-3-fluoro-N-[2-(methyloxy)-5-nitrophenyl]benzenesulfonamide

3-fluoro-4-(5-methyl-2-furanyl)-N-[2-(methyloxy)-5-nitrophenyl]benzenesulfonamide

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