Technology Process of HO-D-Hpla(TIPS)-D-Phe(4-F)-O-t-Bu
There total 8 articles about HO-D-Hpla(TIPS)-D-Phe(4-F)-O-t-Bu which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 5.70 g / triethylamine / dimethylformamide / 2 h / 20 °C
2.1: La(O-i-Pr)3; (S)-BINOL; 4 A molecular sieves / triphenylphosphine oxide / tetrahydrofuran; decane / 1.5 h / 20 °C
3.1: 20 °C
3.2: Pd/C; H2 / tetrahydrofuran
With
lanthanum(III) isopropoxide; 4 A molecular sieve; (S)-[1,1']-binaphthalenyl-2,2'-diol; triethylamine;
Triphenylphosphine oxide;
In
tetrahydrofuran; decane; N,N-dimethyl-formamide;
DOI:10.1021/ja037290e
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 1-ethyl-3-(dimethylaminopropyl)carbodiimide hydrochloride / dimethylformamide / 12 h / 20 °C
2.1: 5.70 g / triethylamine / dimethylformamide / 2 h / 20 °C
3.1: La(O-i-Pr)3; (S)-BINOL; 4 A molecular sieves / triphenylphosphine oxide / tetrahydrofuran; decane / 1.5 h / 20 °C
4.1: 20 °C
4.2: Pd/C; H2 / tetrahydrofuran
With
lanthanum(III) isopropoxide; 4 A molecular sieve; (S)-[1,1']-binaphthalenyl-2,2'-diol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
Triphenylphosphine oxide;
In
tetrahydrofuran; decane; N,N-dimethyl-formamide;
DOI:10.1021/ja037290e
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 5.70 g / triethylamine / dimethylformamide / 2 h / 20 °C
2.1: La(O-i-Pr)3; (S)-BINOL; 4 A molecular sieves / triphenylphosphine oxide / tetrahydrofuran; decane / 1.5 h / 20 °C
3.1: 20 °C
3.2: Pd/C; H2 / tetrahydrofuran
With
lanthanum(III) isopropoxide; 4 A molecular sieve; (S)-[1,1']-binaphthalenyl-2,2'-diol; triethylamine;
Triphenylphosphine oxide;
In
tetrahydrofuran; decane; N,N-dimethyl-formamide;
DOI:10.1021/ja037290e