8-phenylisothiochroman-1-one

Base Information

Chemical Name:8-phenylisothiochroman-1-one
CAS No.:1382034-29-8
Molecular Formula:C₁₅H₁₂OS
Molecular Weight:240.326
Hs Code.:

Synonyms:8-phenylisothiochroman-1-one

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Chemical Property of 8-phenylisothiochroman-1-one

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Technology Process of 8-phenylisothiochroman-1-one

There total 5 articles about 8-phenylisothiochroman-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1382034-28-7
1-oxoisothiochroman-8-yl trifluoromethanesulfonate

: 98-80-6
phenylboronic acid

: 1382034-29-8
8-phenylisothiochroman-1-one

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In toluene; at 110 ℃; for 2.5h;
DOI:10.1021/jm300488m

Reference yield:

: 378242-08-1
2,2-dimethyl-5-vinyl-4H-benzo[d][1,3]dioxin-4-one

: 1382034-29-8
8-phenylisothiochroman-1-one

Guidance literature:: Multi-step reaction with 5 steps

1: 2,2'-azobis(isobutyronitrile) / toluene / 4 h / 80 °C

2: tris(2-carboxyethyl)phosphine; sodium hydroxide / methanol; water / 3.5 h / 65 °C

3: toluene-4-sulfonic acid / toluene / 24 h / 110 °C

4: pyridine / dichloromethane / 4.5 h

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / toluene / 2.5 h / 110 °C

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,2'-azobis(isobutyronitrile); tris(2-carboxyethyl)phosphine; caesium carbonate; toluene-4-sulfonic acid; sodium hydroxide; In methanol; dichloromethane; water; toluene; 5: Suzuki coupling;
DOI:10.1021/jm300488m

Reference yield:

: 164014-40-8
2,2-dimethyl-5-trifluoromethylsulfonyloxy-4H-(1,3)benzodioxin-4-one

: 1382034-29-8
8-phenylisothiochroman-1-one

Guidance literature:: Multi-step reaction with 6 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / 5 h / 80 °C / Inert atmosphere

2: 2,2'-azobis(isobutyronitrile) / toluene / 4 h / 80 °C

3: tris(2-carboxyethyl)phosphine; sodium hydroxide / methanol; water / 3.5 h / 65 °C

4: toluene-4-sulfonic acid / toluene / 24 h / 110 °C

5: pyridine / dichloromethane / 4.5 h

6: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / toluene / 2.5 h / 110 °C

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,2'-azobis(isobutyronitrile); tris(2-carboxyethyl)phosphine; potassium carbonate; caesium carbonate; toluene-4-sulfonic acid; sodium hydroxide; In methanol; 1,2-dimethoxyethane; dichloromethane; water; toluene; 1: Suzuki coupling / 6: Suzuki coupling;
DOI:10.1021/jm300488m