(2R,3S)-2-[[(1,1-dimethylethyl)(dimethyl)silyl]oxy]-3-hydroxy-5-phenylpentanoic acid methyl ester

Base Information

• Chemical Name: (2R,3S)-2-[[(1,1-dimethylethyl)(dimethyl)silyl]oxy]-3-hydroxy-5-phenylpentanoic acid methyl ester
• CAS No.: 1021491-70-2
• Molecular Formula: C₁₈H₃₀O₄Si
• Molecular Weight: 338.519

Synonyms:(2R,3S)-2-[[(1,1-dimethylethyl)(dimethyl)silyl]oxy]-3-hydroxy-5-phenylpentanoic acid methyl ester

Chemical Property of (2R,3S)-2-[[(1,1-dimethylethyl)(dimethyl)silyl]oxy]-3-hydroxy-5-phenylpentanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3S)-2-[[(1,1-dimethylethyl)(dimethyl)silyl]oxy]-3-hydroxy-5-phenylpentanoic acid methyl ester

There total 3 articles about (2R,3S)-2-[[(1,1-dimethylethyl)(dimethyl)silyl]oxy]-3-hydroxy-5-phenylpentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,3S,4E)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-hydroxy-5-phenyl-4-pentenoic acid methyl ester (1021491-73-5) → (2R,3S)-2-[[(1,1-dimethylethyl)(dimethyl)silyl]oxy]-3-hydroxy-5-phenylpentanoic acid methyl ester (1021491-70-2)

Guidance literature:

With hydrogen; platinum on activated charcoal; In ethanol; at 20 ℃; for 6h; under 760.051 Torr;

DOI:10.1021/jo8006539

Reference yield:

3-phenyl-propionaldehyde (104-53-0) + (Z)-2-(tert-Butyldimethylsiloxy)-1-methoxy-1-(trimethylsiloxy)ethene (150811-51-1) → (2S,3R)-2-[[(1,1-dimethylethyl)(dimethyl)silyl]oxy]-3-hydroxy-5-phenylpentanoic acid methyl ester + (2R,3S)-2-[[(1,1-dimethylethyl)(dimethyl)silyl]oxy]-3-hydroxy-5-phenylpentanoic acid methyl ester (1021491-70-2) + 2-[[(1,1-dimethylethyl)(dimethyl)silyl]oxy]-3-hydroxy-5-phenylpentanoic acid methyl ester

Guidance literature:

With tin(IV) chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -50 ℃; for 20h; Title compound not separated from byproducts.;

DOI:10.1002/anie.200705499

Reference yield:

3-phenyl-propionaldehyde (104-53-0) + (Z)-2-(tert-Butyldimethylsiloxy)-1-methoxy-1-(trimethylsiloxy)ethene (150811-51-1) → 2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-hydroxy-5-phenylpentanoic acid methyl ester + (2S,3R)-2-[[(1,1-dimethylethyl)(dimethyl)silyl]oxy]-3-hydroxy-5-phenylpentanoic acid methyl ester + (2R,3S)-2-[[(1,1-dimethylethyl)(dimethyl)silyl]oxy]-3-hydroxy-5-phenylpentanoic acid methyl ester (1021491-70-2)

Guidance literature:

With tetrachlorosilane; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -50 ℃; for 20h; Title compound not separated from byproducts.;

DOI:10.1021/jo8006539

upstream raw materials:

3-phenyl-propionaldehyde

(Z)-2-(tert-Butyldimethylsiloxy)-1-methoxy-1-(trimethylsiloxy)ethene

(2R,3S,4E)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-hydroxy-5-phenyl-4-pentenoic acid methyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1021491-70-2 (2R,3S)-2-[[(1,1-dimethylethyl)(dimethyl)silyl]oxy]-3-hydroxy-5-phenylpentanoic acid methyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send