1-(2',3',5'-tri-O-benzoate-β-D-ribofuranosyl)-5-cyanouridine

Base Information

• Chemical Name: 1-(2',3',5'-tri-O-benzoate-β-D-ribofuranosyl)-5-cyanouridine
• CAS No.: 14048-09-0
• Molecular Formula: C₃₁H₂₃N₃O₉
• Molecular Weight: 581.538
• Mol file: 14048-09-0.mol

Synonyms:1-(2',3',5'-tri-O-benzoate-β-D-ribofuranosyl)-5-cyanouridine

Chemical Property of 1-(2',3',5'-tri-O-benzoate-β-D-ribofuranosyl)-5-cyanouridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2',3',5'-tri-O-benzoate-β-D-ribofuranosyl)-5-cyanouridine

There total 3 articles about 1-(2',3',5'-tri-O-benzoate-β-D-ribofuranosyl)-5-cyanouridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose (67525-66-0) + C11H19N3O2Si2 → 1-(2',3',5'-tri-O-benzoate-β-D-ribofuranosyl)-5-cyanouridine (14048-09-0)

Guidance literature:

With tin(IV) chloride; In 1,2-dichloro-ethane; at 0 - 20 ℃; for 2.5h;

DOI:10.1002/cbic.201800399

Reference yield:

2,3,5-tri-O-benzoyl-β-D-ribofuranosyl azide (7408-41-5) → 1-(2',3',5'-tri-O-benzoate-β-D-ribofuranosyl)-5-cyanouridine (14048-09-0)

Guidance literature:

With ethyl acetate; platinum; Hydrogenation.Beim Erwaermen des Reaktionsprodukts mit <3-Aethoxy-2-cyan-acryloyl>-carbamidsaeure-aethylester in Gegenwart von Triaethylamin;

Reference yield:

→ 1-(2',3',5'-tri-O-benzoate-β-D-ribofuranosyl)-5-cyanouridine (14048-09-0)

Guidance literature:

Quecksilbersalz von 5-Cyano-uracil, Toluol, 2,3,5-Tri-O-benzoyl-D-ribofuranosylchlorid, Siedetemp., Acetonitril;

upstream raw materials:

2,3,5-tri-O-benzoyl-β-D-ribofuranosyl azide

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose