ethyl (6-chloro-2-(methylthio)-5-nitropyrimidin-4-yl)(3-methoxybenzyl)carbamate

Base Information

Chemical Name:ethyl (6-chloro-2-(methylthio)-5-nitropyrimidin-4-yl)(3-methoxybenzyl)carbamate
CAS No.:1539303-99-5
Molecular Formula:C₁₆H₁₇ClN₄O₅S
Molecular Weight:412.854
Hs Code.:

Synonyms:ethyl (6-chloro-2-(methylthio)-5-nitropyrimidin-4-yl)(3-methoxybenzyl)carbamate

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Chemical Property of ethyl (6-chloro-2-(methylthio)-5-nitropyrimidin-4-yl)(3-methoxybenzyl)carbamate

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Technology Process of ethyl (6-chloro-2-(methylthio)-5-nitropyrimidin-4-yl)(3-methoxybenzyl)carbamate

There total 7 articles about ethyl (6-chloro-2-(methylthio)-5-nitropyrimidin-4-yl)(3-methoxybenzyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1434589-59-9
ethyl (6-chloro-2-(methylthio)-5-nitropyrimidin-4-yl)carbamate

: 874-98-6
1-bromomethyl-3-methoxybenzene

: 1539303-99-5
ethyl (6-chloro-2-(methylthio)-5-nitropyrimidin-4-yl)(3-methoxybenzyl)carbamate

Guidance literature:: With potassium carbonate; sodium iodide; In acetone; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.5b01760

Reference yield: 58.0%

: 1434589-59-9
ethyl (6-chloro-2-(methylthio)-5-nitropyrimidin-4-yl)carbamate

: 824-98-6
m-methoxybenzyl chloride

: 1539303-99-5
ethyl (6-chloro-2-(methylthio)-5-nitropyrimidin-4-yl)(3-methoxybenzyl)carbamate

Guidance literature:: With potassium carbonate; sodium iodide; In acetone; at 20 ℃; for 16h;

Reference yield:

: 38136-96-8
6-chloro-2-(methylsulfanyl)-5-nitropyrimidin-4-amine

: 1539303-99-5
ethyl (6-chloro-2-(methylthio)-5-nitropyrimidin-4-yl)(3-methoxybenzyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 6 h / 20 °C

2: potassium carbonate; sodium iodide / acetone / 16 h / 20 °C

With potassium carbonate; triethylamine; sodium iodide; In tetrahydrofuran; acetone;