(S)-2-((3S,6S)-1-Carboxymethyl-2-oxo-6-phenyl-azepan-3-ylamino)-4-phenyl-butyric acid

Base Information

Chemical Name:(S)-2-((3S,6S)-1-Carboxymethyl-2-oxo-6-phenyl-azepan-3-ylamino)-4-phenyl-butyric acid
CAS No.:111820-50-9
Molecular Formula:C₂₄H₂₈N₂O₅
Molecular Weight:424.497
Hs Code.:

Synonyms:(S)-2-((3S,6S)-1-Carboxymethyl-2-oxo-6-phenyl-azepan-3-ylamino)-4-phenyl-butyric acid

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Chemical Property of (S)-2-((3S,6S)-1-Carboxymethyl-2-oxo-6-phenyl-azepan-3-ylamino)-4-phenyl-butyric acid

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Technology Process of (S)-2-((3S,6S)-1-Carboxymethyl-2-oxo-6-phenyl-azepan-3-ylamino)-4-phenyl-butyric acid

There total 14 articles about (S)-2-((3S,6S)-1-Carboxymethyl-2-oxo-6-phenyl-azepan-3-ylamino)-4-phenyl-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 111820-54-3
(S)-2-((3S,6S)-1-Carboxymethyl-2-oxo-6-phenyl-azepan-3-ylamino)-4-phenyl-butyric acid ethyl ester; hydrochloride

: 111820-50-9
(S)-2-((3S,6S)-1-Carboxymethyl-2-oxo-6-phenyl-azepan-3-ylamino)-4-phenyl-butyric acid

Guidance literature:: With sodium hydroxide;
DOI:10.1021/jm00397a027

Reference yield:

: 112093-43-3
Phenyl-6 tetrahydro-4,5,6,7 <3H>azepinone-2

: 111820-50-9
(S)-2-((3S,6S)-1-Carboxymethyl-2-oxo-6-phenyl-azepan-3-ylamino)-4-phenyl-butyric acid

Guidance literature:: Multi-step reaction with 7 steps

1: 63 percent / PCl₅, I₂, Br₂ / CH₂Cl₂ / 1.5 h / Ambient temperature

2: 25 percent / NaN₃ / dimethylformamide / 4 h / 60 °C

3: NaH / dimethylformamide; paraffin

4: H₂ / Pd-C / ethanol

5: 40 percent / Et₃N / CH₂Cl₂

6: 75 percent / 4N HCl / dioxane / Ambient temperature

7: 95 percent / 1N NaOH

With hydrogenchloride; sodium hydroxide; sodium azide; phosphorus pentachloride; hydrogen; bromine; iodine; sodium hydride; triethylamine; palladium on activated charcoal; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; paraffin;
DOI:10.1021/jm00397a027

Reference yield:

: 140-29-4
phenylacetonitrile

: 111820-50-9
(S)-2-((3S,6S)-1-Carboxymethyl-2-oxo-6-phenyl-azepan-3-ylamino)-4-phenyl-butyric acid

Guidance literature:: Multi-step reaction with 14 steps

1: 58 percent / NaH / dimethylformamide; paraffin / 4 h / Ambient temperature

2: H₂ / Raney-Ni / ethanol / 2.5 h / 40 °C

3: 30 percent / Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

4: aq. NaOH / ethanol / 1 h / Ambient temperature

5: 87 percent / DCC / CH₂Cl₂ / Ambient temperature

6: 95 percent / 4N HCl / dioxane / 1.5 h / Ambient temperature

7: 78 percent / Et₃N / CH₂Cl₂ / Ambient temperature

8: 63 percent / PCl₅, I₂, Br₂ / CH₂Cl₂ / 1.5 h / Ambient temperature

9: 25 percent / NaN₃ / dimethylformamide / 4 h / 60 °C

10: NaH / dimethylformamide; paraffin

11: H₂ / Pd-C / ethanol

12: 40 percent / Et₃N / CH₂Cl₂

13: 75 percent / 4N HCl / dioxane / Ambient temperature

14: 95 percent / 1N NaOH

With hydrogenchloride; sodium hydroxide; sodium azide; phosphorus pentachloride; hydrogen; bromine; iodine; sodium hydride; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; nickel; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; paraffin;
DOI:10.1021/jm00397a027