Technology Process of (+/-)-Hermitamide A
There total 7 articles about (+/-)-Hermitamide A which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
benzotriazol-1-ol; diisopropyl-carbodiimide;
In
dichloromethane;
at 20 ℃;
for 15h;
DOI:10.1016/j.bmc.2011.05.043
- Guidance literature:
-
Multi-step reaction with 2 steps
1: lithium hydroxide / tetrahydrofuran; water / 18 h / 20 °C
2: benzotriazol-1-ol; diisopropyl-carbodiimide / dichloromethane / 15 h / 20 °C
With
benzotriazol-1-ol; lithium hydroxide; diisopropyl-carbodiimide;
In
tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.bmc.2011.05.043
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: diethyl ether / 18 h / 20 °C
1.2: Saturated solution
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 10 h / Reflux
3.1: sodium periodate; osmium(VIII) oxide / ethanol; water; tert-butyl alcohol / 18.5 h / 20 °C
4.1: tetrahydrofuran / 3 h / 20 °C
4.2: Saturated solution
5.1: propionic acid / 1.5 h / 100 °C
6.1: lithium hydroxide / tetrahydrofuran; water / 18 h / 20 °C
7.1: benzotriazol-1-ol; diisopropyl-carbodiimide / dichloromethane / 15 h / 20 °C
With
sodium periodate; osmium(VIII) oxide; sodium hydride; benzotriazol-1-ol; propionic acid; lithium hydroxide; diisopropyl-carbodiimide;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil; tert-butyl alcohol;
5.1: Johnson-Claisen rearrangement;
DOI:10.1016/j.bmc.2011.05.043
