4-(4-(5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-ylamino)-6-morpholinopyridin-3-yl)-2-methoxybenzonitrile

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Chemical Name:4-(4-(5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-ylamino)-6-morpholinopyridin-3-yl)-2-methoxybenzonitrile
CAS No.:1354285-86-1
Molecular Formula:C₃₂H₂₆F₂N₆O₂
Molecular Weight:564.594
Hs Code.:

Synonyms:4-(4-(5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-ylamino)-6-morpholinopyridin-3-yl)-2-methoxybenzonitrile

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Chemical Property of 4-(4-(5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-ylamino)-6-morpholinopyridin-3-yl)-2-methoxybenzonitrile

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Technology Process of 4-(4-(5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-ylamino)-6-morpholinopyridin-3-yl)-2-methoxybenzonitrile

There total 2 articles about 4-(4-(5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-ylamino)-6-morpholinopyridin-3-yl)-2-methoxybenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1259439-36-5
4-chloro-5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinoline

: 1354290-81-5
4-(4-amino-6-morpholinopyridin-3-yl)-2-methoxybenzonitrile

: 1354285-86-1
4-(4-(5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-ylamino)-6-morpholinopyridin-3-yl)-2-methoxybenzonitrile

Guidance literature:: With sodium t-butanolate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In toluene; at 100 ℃; for 18h; Inert atmosphere;

Reference yield:

: 1354288-32-6
5-bromo-2-morpholinopyridin-4-amine

: 1354285-86-1
4-(4-(5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-ylamino)-6-morpholinopyridin-3-yl)-2-methoxybenzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 19 h / 90 °C

2: sodium t-butanolate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 18 h / 100 °C / Inert atmosphere

With sodium carbonate; sodium t-butanolate; XPhos; bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; toluene;