Talipexole

Base Information

Chemical Name:Talipexole
CAS No.:101626-70-4
Molecular Formula:C₁₀H₁₅N₃S
Molecular Weight:209.315
Hs Code.:
UNII:7AM2J46Z1Y
DSSTox Substance ID:DTXSID8046321
Nikkaji Number:J33.385I
Wikipedia:Talipexole
Wikidata:Q7679540
NCI Thesaurus Code:C152496
Pharos Ligand ID:JXV4NFZUNHXD
ChEMBL ID:CHEMBL279085
Mol file:101626-70-4.mol

Synonyms:2-amino-6-allyl-5,6,7,8-tetrahydro-4H-thiazolo-(5,4-d)azepin-dihydrochloride;6-allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo(4,5-d)azepin dihydrochloride;B HT920;B-HT 920;BHT 920;BHT920;talipexole

Suppliers and Price of Talipexole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Talipexole 98+%
50mg
$ 438.00

Crysdot
Talipexole 98+%
10mg
$ 102.00

Crysdot
Talipexole 98+%
5mg
$ 76.00

Crysdot
Talipexole 98+%
100mg
$ 805.00

AvaChem
Talipexole
1g
$ 2900.00

AvaChem
Talipexole
100mg
$ 690.00

American Custom Chemicals Corporation
TALIPEXOLE 95.00%
10MG
$ 520.00

American Custom Chemicals Corporation
TALIPEXOLE 95.00%
5MG
$ 490.00

American Custom Chemicals Corporation
TALIPEXOLE 95.00%
50MG
$ 920.00

AHH
Talipexole 98%
0.5g
$ 800.00

Total 18 raw suppliers

Chemical Property of Talipexole

Chemical Property:

Vapor Pressure:1.66E-05mmHg at 25°C
Boiling Point:364.6°Cat760mmHg
PKA:7.22±0.20(Predicted)
Flash Point:174.3°C
PSA：70.39000
Density:1.167g/cm³
LogP:3.43500
XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:209.09866866
Heavy Atom Count:14
Complexity:210

Purity/Quality:

97% ^*data from raw suppliers

Talipexole 98+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C=CCN1CCC2=C(CC1)SC(=N2)N
Description Domin was launched in Japan for Parkinson's disease. The compound is readily accessible in two steps from I-allylhexahydro-4H-azepin4-one. Its antiparkinson activity resides in the fact that talipexole is a selective agonist for presynaptic dopamine D2 receptors with no D1 receptor activity. It is a clonidine-like α2-adrenoreptor agonist and has fewer GI side effects than bromocriptine the most widely used dopamine angonist. Also it is 70 times more potent than bromocriptine and has a more rapid onset of action. In addition to its anti-tremor activity there was a sedative effect but no emesis. The latter probably a result of talipexole's 5-HT3 receptor antagonistic activity. Its metabolites have no biological activity, there was no development of tolerence and its effect could be enhanced by L-dopa.

Technology Process of Talipexole

There total 1 articles about Talipexole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: