N-[1,1-bis(hydroxymethyl)-3-(4-methoxy-3-trifluoromethylphenyl)propyl]acetamide

Base Information

Chemical Name:N-[1,1-bis(hydroxymethyl)-3-(4-methoxy-3-trifluoromethylphenyl)propyl]acetamide
CAS No.:942399-46-4
Molecular Formula:C₁₅H₂₀F₃NO₄
Molecular Weight:335.323
Hs Code.:

Synonyms:N-[1,1-bis(hydroxymethyl)-3-(4-methoxy-3-trifluoromethylphenyl)propyl]acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[1,1-bis(hydroxymethyl)-3-(4-methoxy-3-trifluoromethylphenyl)propyl]acetamide

Chemical Property:

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Technology Process of N-[1,1-bis(hydroxymethyl)-3-(4-methoxy-3-trifluoromethylphenyl)propyl]acetamide

There total 1 articles about N-[1,1-bis(hydroxymethyl)-3-(4-methoxy-3-trifluoromethylphenyl)propyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 942399-45-3
2-acetamido-2-[2-(4-methoxy-3-trifluoromethylphenyl)ethyl]malonic acid diethyl ester

: 942399-46-4
N-[1,1-bis(hydroxymethyl)-3-(4-methoxy-3-trifluoromethylphenyl)propyl]acetamide

Guidance literature:: 2-acetamido-2-[2-(4-methoxy-3-trifluoromethylphenyl)ethyl]malonic acid diethyl ester; With sodium tetrahydroborate; calcium chloride; In ethanol; water; at 0 - 20 ℃; for 23h;

With hydrogenchloride; water; In ethanol; at 0 ℃;

Reference yield:

: 942399-46-4
N-[1,1-bis(hydroxymethyl)-3-(4-methoxy-3-trifluoromethylphenyl)propyl]acetamide

: 24424-99-5
di-tert-butyl dicarbonate

: 942399-47-5
[1,1-bis(hydroxymethyl)-3-(4-hydroxy-3-trifluoromethylphenyl)propyl]carbamic acid t-butyl ester

Guidance literature:: N-[1,1-bis(hydroxymethyl)-3-(4-methoxy-3-trifluoromethylphenyl)propyl]acetamide; With boron tribromide; In dichloromethane; at -70 - 0 ℃; for 3h;

With hydrogenchloride; water; In ethanol; at 70 ℃; for 1h;

di-tert-butyl dicarbonate; With N-ethyl-N,N-diisopropylamine; In methanol; at 0 - 20 ℃; for 6h;

Reference yield:

: 942399-46-4
N-[1,1-bis(hydroxymethyl)-3-(4-methoxy-3-trifluoromethylphenyl)propyl]acetamide

: 10294-33-4
boron tribromide

: C₁₂H₁₆F₃NO₃

Guidance literature:: N-[1,1-bis(hydroxymethyl)-3-(4-methoxy-3-trifluoromethylphenyl)propyl]acetamide; boron tribromide; In dichloromethane; at -70 - 0 ℃; for 3h; Ice-cooling;

With methanol; In dichloromethane; Ice-cooling;

With hydrogenchloride; water; In dichloromethane; at 70 ℃; for 1h;