Technology Process of (E)-1-(1,3-dithian-2-yl)-2-phenylbut-2-en-1-ol
There total 1 articles about (E)-1-(1,3-dithian-2-yl)-2-phenylbut-2-en-1-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1,3 dithiane;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -20 ℃;
for 1h;
Inert atmosphere;
2-phenyl-2-butenal;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 0.5h;
Inert atmosphere;
DOI:10.1021/ja2105703
- Guidance literature:
-
C9H15NOSi;
With
titanium(IV) isopropylate; cyclopentylmagnesium chloride;
In
tetrahydrofuran; diethyl ether;
at -78 - -30 ℃;
for 1.5h;
Inert atmosphere;
(E)-1-(1,3-dithian-2-yl)-2-phenylbut-2-en-1-ol;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 - 0 ℃;
for 0.166667h;
Inert atmosphere;
In
tetrahydrofuran; diethyl ether; hexane;
at 0 - 20 ℃;
optical yield given as %de;
stereoselective reaction;
Inert atmosphere;
DOI:10.1021/ja2105703
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: titanium(IV) isopropylate; cyclopentylmagnesium chloride / tetrahydrofuran; diethyl ether / 1.5 h / -78 - -30 °C / Inert atmosphere
1.2: 0.17 h / -78 - 0 °C / Inert atmosphere
1.3: 0 - 20 °C / Inert atmosphere
2.1: silver nitrate / tetrahydrofuran; water / 60 °C / Inert atmosphere
With
titanium(IV) isopropylate; cyclopentylmagnesium chloride; silver nitrate;
In
tetrahydrofuran; diethyl ether; water;
DOI:10.1021/ja2105703
