(1S,2S,4R)-4-(4-((S)-2,3-dihydro-1H-inden-1-ylamino)furo[3,2-d]pyrimidin-7-yl)-2-(sulfamoyloxymethyl)cyclopentyl 4-nitrobenzoate

Base Information

Chemical Name:(1S,2S,4R)-4-(4-((S)-2,3-dihydro-1H-inden-1-ylamino)furo[3,2-d]pyrimidin-7-yl)-2-(sulfamoyloxymethyl)cyclopentyl 4-nitrobenzoate
CAS No.:1370008-64-2
Molecular Formula:C₂₈H₂₇N₅O₈S
Molecular Weight:593.617
Hs Code.:

Synonyms:(1S,2S,4R)-4-(4-((S)-2,3-dihydro-1H-inden-1-ylamino)furo[3,2-d]pyrimidin-7-yl)-2-(sulfamoyloxymethyl)cyclopentyl 4-nitrobenzoate

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Chemical Property of (1S,2S,4R)-4-(4-((S)-2,3-dihydro-1H-inden-1-ylamino)furo[3,2-d]pyrimidin-7-yl)-2-(sulfamoyloxymethyl)cyclopentyl 4-nitrobenzoate

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Technology Process of (1S,2S,4R)-4-(4-((S)-2,3-dihydro-1H-inden-1-ylamino)furo[3,2-d]pyrimidin-7-yl)-2-(sulfamoyloxymethyl)cyclopentyl 4-nitrobenzoate

There total 15 articles about (1S,2S,4R)-4-(4-((S)-2,3-dihydro-1H-inden-1-ylamino)furo[3,2-d]pyrimidin-7-yl)-2-(sulfamoyloxymethyl)cyclopentyl 4-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1370008-62-0
(1S,2S,4R)-4-(4-((S)-2,3-dihydro-1H-inden-1-ylamino)furo[3,2-d]pyrimidin-7-yl)-2-(hydroxymethyl)cyclopentyl 4-nitrobenzoate

: 1370008-64-2
(1S,2S,4R)-4-(4-((S)-2,3-dihydro-1H-inden-1-ylamino)furo[3,2-d]pyrimidin-7-yl)-2-(sulfamoyloxymethyl)cyclopentyl 4-nitrobenzoate

Guidance literature:: With sulphamoyl chloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; acetonitrile; at 0 - 20 ℃; for 4h;

Reference yield:

: ((1R,2S)-2-(benzyloxymethyl)cyclopent-3-enyloxy)(tert-butyl)diphenylsilane

: 1370008-64-2
(1S,2S,4R)-4-(4-((S)-2,3-dihydro-1H-inden-1-ylamino)furo[3,2-d]pyrimidin-7-yl)-2-(sulfamoyloxymethyl)cyclopentyl 4-nitrobenzoate

Guidance literature:: Multi-step reaction with 13 steps

1.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 20 h / 0 - 20 °C

1.2: 3 h / 0 - 20 °C

1.3: 3 h / -78 - 20 °C

2.1: n-butyllithium / tetrahydrofuran / 0.17 h / -78 °C

2.2: 0.83 h / -78 °C

3.1: thionyl chloride / pyridine / 2 h / 0 - 20 °C

4.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h

5.1: N,N-dimethyl-formamide / 20 h / 95 °C

5.2: 2 h / 20 °C

6.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

7.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C

8.1: toluene / 2 h / 110 °C

9.1: pyridine; acetic acid / acetonitrile / 1.5 h / 110 °C / Microwave irradiation

10.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 20 °C

11.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 20 °C

12.1: boron trichloride / dichloromethane / 2 h / -78 °C

13.1: sulphamoyl chloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide; acetonitrile / 4 h / 0 - 20 °C

With pyridine; n-butyllithium; thionyl chloride; sulphamoyl chloride; tetrabutyl ammonium fluoride; hydrogen; boron trichloride; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; 9-bora-bicyclo[3.3.1]nonane; triphenylphosphine; lithium diisopropyl amide; diethylazodicarboxylate; palladium 10% on activated carbon; In tetrahydrofuran; pyridine; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 188399-48-6
(1R,2S)-2-((benzyloxy)methyl)cyclopent-3-en-1-ol

: 1370008-64-2
(1S,2S,4R)-4-(4-((S)-2,3-dihydro-1H-inden-1-ylamino)furo[3,2-d]pyrimidin-7-yl)-2-(sulfamoyloxymethyl)cyclopentyl 4-nitrobenzoate

Guidance literature:: Multi-step reaction with 14 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 3 h / 20 °C / Cooling

2.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 20 h / 0 - 20 °C

2.2: 3 h / 0 - 20 °C

2.3: 3 h / -78 - 20 °C

3.1: n-butyllithium / tetrahydrofuran / 0.17 h / -78 °C

3.2: 0.83 h / -78 °C

4.1: thionyl chloride / pyridine / 2 h / 0 - 20 °C

5.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h

6.1: N,N-dimethyl-formamide / 20 h / 95 °C

6.2: 2 h / 20 °C

7.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

8.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C

9.1: toluene / 2 h / 110 °C

10.1: pyridine; acetic acid / acetonitrile / 1.5 h / 110 °C / Microwave irradiation

11.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 20 °C

12.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 20 °C

13.1: boron trichloride / dichloromethane / 2 h / -78 °C

14.1: sulphamoyl chloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide; acetonitrile / 4 h / 0 - 20 °C

With pyridine; 1H-imidazole; n-butyllithium; thionyl chloride; sulphamoyl chloride; tetrabutyl ammonium fluoride; hydrogen; boron trichloride; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; 9-bora-bicyclo[3.3.1]nonane; triphenylphosphine; lithium diisopropyl amide; diethylazodicarboxylate; palladium 10% on activated carbon; In tetrahydrofuran; pyridine; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;