5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-methyl-2,5-dihydro-furan-2-ol

Base Information

• Chemical Name: 5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-methyl-2,5-dihydro-furan-2-ol
• CAS No.: 220020-64-4
• Molecular Formula: C₂₂H₂₈O₃Si
• Molecular Weight: 368.548
• Mol file: 220020-64-4.mol

Synonyms:5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-methyl-2,5-dihydro-furan-2-ol

Chemical Property of 5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-methyl-2,5-dihydro-furan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-methyl-2,5-dihydro-furan-2-ol

There total 5 articles about 5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-methyl-2,5-dihydro-furan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-methyl-5H-furan-2-one (220020-63-3) → 5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-methyl-2,5-dihydro-furan-2-ol (220020-64-4)

Guidance literature:

With diisobutylaluminium hydride; In toluene; at -79 ℃; for 3h;

DOI:10.1021/jo972264i

Reference yield:

5-Acetoxymethyl-2,3-dimethyl-isoxazolidine-3-carboxylic acid methyl ester (220020-51-9) → 5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-methyl-2,5-dihydro-furan-2-ol (220020-64-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 100 percent / CCl₄ / 3 h / 0 °C

2: 96 percent / H₂ / Pd/C / methanol / 36 h / 70 °C

3: 47 percent / imidazole / CH₂Cl₂ / 3 h / 0 °C

4: 99 percent / m-CPBA / CH₂Cl₂ / 3 h / 25 °C

5: 87 percent / DIBALH / toluene / 3 h / -79 °C

With 1H-imidazole; hydrogen; diisobutylaluminium hydride; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In methanol; tetrachloromethane; dichloromethane; toluene;

DOI:10.1021/jo972264i

Reference yield:

Trifluoro-methanesulfonate5-acetoxymethyl-3-methoxycarbonyl-2,2,3-trimethyl-isoxazolidin-2-ium; → 5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-methyl-2,5-dihydro-furan-2-ol (220020-64-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 96 percent / H₂ / Pd/C / methanol / 36 h / 70 °C

2: 47 percent / imidazole / CH₂Cl₂ / 3 h / 0 °C

3: 99 percent / m-CPBA / CH₂Cl₂ / 3 h / 25 °C

4: 87 percent / DIBALH / toluene / 3 h / -79 °C

With 1H-imidazole; hydrogen; diisobutylaluminium hydride; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In methanol; dichloromethane; toluene;

DOI:10.1021/jo972264i

upstream raw materials:

5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-methyl-5H-furan-2-one

3-Dimethylamino-5-hydroxymethyl-3-methyl-dihydro-furan-2-one

5-Acetoxymethyl-2,3-dimethyl-isoxazolidine-3-carboxylic acid methyl ester