(S,E)-2-(2,6-dichlorobenzamido)-5-[4-(isopropyl-pyrimidin-2-ylamino)phenyl]pent-4-enoic acid

Base Information

• Chemical Name: (S,E)-2-(2,6-dichlorobenzamido)-5-[4-(isopropyl-pyrimidin-2-ylamino)phenyl]pent-4-enoic acid
• CAS No.: 894404-80-9
• Molecular Formula: C₂₅H₂₄Cl₂N₄O₃
• Molecular Weight: 499.397
• Mol file: 894404-80-9.mol

Synonyms:(S,E)-2-(2,6-dichlorobenzamido)-5-[4-(isopropyl-pyrimidin-2-ylamino)phenyl]pent-4-enoic acid

Chemical Property of (S,E)-2-(2,6-dichlorobenzamido)-5-[4-(isopropyl-pyrimidin-2-ylamino)phenyl]pent-4-enoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S,E)-2-(2,6-dichlorobenzamido)-5-[4-(isopropyl-pyrimidin-2-ylamino)phenyl]pent-4-enoic acid

There total 8 articles about (S,E)-2-(2,6-dichlorobenzamido)-5-[4-(isopropyl-pyrimidin-2-ylamino)phenyl]pent-4-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S,E)-2-(2,6-dichlorobenzamido)-5-[4-(isopropyl-pyrimidin-2-ylamino)phenyl]pent-4-enoic acid methyl ester (894404-77-4) → (S,E)-2-(2,6-dichlorobenzamido)-5-[4-(isopropyl-pyrimidin-2-ylamino)phenyl]pent-4-enoic acid (894404-80-9)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; water; at 0 ℃; for 0.666667h;

Reference yield:

(S,E)-2-(2,6-dichlorobenzamido)-5-[4-(isopropyl-pyrimidin-2-ylamino)phenyl]pent-4-enoic acid methyl ester (894404-77-4) + aqueous lithium hydroxide → (S,E)-2-(2,6-dichlorobenzamido)-5-[4-(isopropyl-pyrimidin-2-ylamino)phenyl]pent-4-enoic acid (894404-80-9)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

N-(4-iodophenyl)pyrimidin-2-amine (894400-24-9) → (S,E)-2-(2,6-dichlorobenzamido)-5-[4-(isopropyl-pyrimidin-2-ylamino)phenyl]pent-4-enoic acid (894404-80-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1.33 h / 20 °C

1.2: 8 h / 20 °C

2.1: potassium carbonate / palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 7 h / 80 °C

3.1: lithium hydroxide; water / tetrahydrofuran / 0.67 h / 0 °C

With lithium hydroxide; water; sodium hydride; potassium carbonate; palladium diacetate; tris-(o-tolyl)phosphine; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

(S,E)-2-(2,6-dichlorobenzamido)-5-[4-(isopropyl-pyrimidin-2-ylamino)phenyl]pent-4-enoic acid methyl ester

N-(4-iodophenyl)pyrimidin-2-amine

N-(4-iodophenyl)-N-isopropylpyrimidin-2-amine

(S)-2-(2,6-dichlorobenzamido)pent-4-enoic acid methyl ester