N-{2-(3,5-dimethyl-pyrazol-1-yl)-6-[3-((R)-1-methyl-pyrrolidin-3-yloxymethyl)phenyl]-pyrimidin-4-yl}-acetamide

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Chemical Name:N-{2-(3,5-dimethyl-pyrazol-1-yl)-6-[3-((R)-1-methyl-pyrrolidin-3-yloxymethyl)phenyl]-pyrimidin-4-yl}-acetamide
CAS No.:1061749-60-7
Molecular Formula:C₂₃H₂₈N₆O₂
Molecular Weight:420.514
Hs Code.:

Synonyms:N-{2-(3,5-dimethyl-pyrazol-1-yl)-6-[3-((R)-1-methyl-pyrrolidin-3-yloxymethyl)phenyl]-pyrimidin-4-yl}-acetamide

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Chemical Property of N-{2-(3,5-dimethyl-pyrazol-1-yl)-6-[3-((R)-1-methyl-pyrrolidin-3-yloxymethyl)phenyl]-pyrimidin-4-yl}-acetamide

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Technology Process of N-{2-(3,5-dimethyl-pyrazol-1-yl)-6-[3-((R)-1-methyl-pyrrolidin-3-yloxymethyl)phenyl]-pyrimidin-4-yl}-acetamide

There total 3 articles about N-{2-(3,5-dimethyl-pyrazol-1-yl)-6-[3-((R)-1-methyl-pyrrolidin-3-yloxymethyl)phenyl]-pyrimidin-4-yl}-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1061750-40-0
methanesulfonic acid 3-[6-acetylamino-2-(3,5-dimethyl-pyrazol-1-yl)-pyrimidin-4-yl]-benzyl ester

: 104641-60-3,99445-21-3
(R)-1-methyl-3-pyrrolidinol

: 1061749-60-7
N-{2-(3,5-dimethyl-pyrazol-1-yl)-6-[3-((R)-1-methyl-pyrrolidin-3-yloxymethyl)phenyl]-pyrimidin-4-yl}-acetamide

Guidance literature:: methanesulfonic acid 3-[6-acetylamino-2-(3,5-dimethyl-pyrazol-1-yl)-pyrimidin-4-yl]-benzyl ester; With sodium iodide; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

(R)-1-methyl-3-pyrrolidinol; With sodium hydride; In N,N-dimethyl-formamide; at 60 ℃; for 12h;

Reference yield:

: 1061750-39-7
N-[-2-(3,5-dimethyl-pyrazol-1-yl)-6-(3-hydroxymethyl-phenyl)-pyrimidin-4-yl]-acetamide

: 104641-60-3,99445-21-3
(R)-1-methyl-3-pyrrolidinol

: 1061749-60-7
N-{2-(3,5-dimethyl-pyrazol-1-yl)-6-[3-((R)-1-methyl-pyrrolidin-3-yloxymethyl)phenyl]-pyrimidin-4-yl}-acetamide

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 12h;
DOI:10.1016/j.bmcl.2008.09.048

Reference yield:

: 1061750-39-7
N-[-2-(3,5-dimethyl-pyrazol-1-yl)-6-(3-hydroxymethyl-phenyl)-pyrimidin-4-yl]-acetamide

: 1061749-60-7
N-{2-(3,5-dimethyl-pyrazol-1-yl)-6-[3-((R)-1-methyl-pyrrolidin-3-yloxymethyl)phenyl]-pyrimidin-4-yl}-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 12 h / 0 - 20 °C

2.1: sodium iodide / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 12 h / 60 °C

With N-ethyl-N,N-diisopropylamine; sodium iodide; In 1,4-dioxane; N,N-dimethyl-formamide;