3,5-di-iodo-5'-<(2-methoxypyridin-4-yl)methyl>-4'-O-methyl-N-trifluoroacetyl-L-thyronine ethyl ester

Base Information

Chemical Name:3,5-di-iodo-5'-<(2-methoxypyridin-4-yl)methyl>-4'-O-methyl-N-trifluoroacetyl-L-thyronine ethyl ester
CAS No.:120130-22-5
Molecular Formula:C₂₇H₂₅F₃I₂N₂O₆
Molecular Weight:784.31
Hs Code.:

Synonyms:3,5-di-iodo-5'-<(2-methoxypyridin-4-yl)methyl>-4'-O-methyl-N-trifluoroacetyl-L-thyronine ethyl ester

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Chemical Property of 3,5-di-iodo-5'-<(2-methoxypyridin-4-yl)methyl>-4'-O-methyl-N-trifluoroacetyl-L-thyronine ethyl ester

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Technology Process of 3,5-di-iodo-5'-<(2-methoxypyridin-4-yl)methyl>-4'-O-methyl-N-trifluoroacetyl-L-thyronine ethyl ester

There total 8 articles about 3,5-di-iodo-5'-<(2-methoxypyridin-4-yl)methyl>-4'-O-methyl-N-trifluoroacetyl-L-thyronine ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13472-85-0,1199266-76-6
2-methoxy-5-bromopyridine

: 120130-22-5
3,5-di-iodo-5'-<(2-methoxypyridin-4-yl)methyl>-4'-O-methyl-N-trifluoroacetyl-L-thyronine ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 72 percent / di-isopropylamine, butyl-lithium / hexane; tetrahydrofuran / -70 deg C, 1.25 h, 0 deg C

2: 67 percent / butyl-lithium, 2.) water / hexane; tetrahydrofuran / -70 deg C, 0.5 h, -65 deg C

3: pyridine / 100 °C

4: 75 percent / H₂ / 10percent Pd/C, 10 M HCl / acetic acid; H₂O / 1.5 h / 2585.7 Torr

5: 37 percent / methanesulphonyl chloride / pyridine / 1.17 h / Heating

6: H₂ / 10percent Pd/C / acetic acid / 1 h / 2585.7 Torr

7: 1.) sulphuric acid, sodium nitrite, 2.) potassium iodide,iodine, urea / 1.) water, -10 deg C, 2.) chloroform, water, RT, 1-2 h

With pyridine; n-butyllithium; sulfuric acid; water; hydrogen; iodine; methanesulfonyl chloride; diisopropylamine; urea; potassium iodide; sodium nitrite; hydrogenchloride; palladium on activated charcoal; In tetrahydrofuran; pyridine; hexane; water; acetic acid;
DOI:10.1039/P19880003085

Reference yield:

: 52329-06-3
5-(benzyloxy)-2-methoxybenzaldehyde

: 120130-22-5
3,5-di-iodo-5'-<(2-methoxypyridin-4-yl)methyl>-4'-O-methyl-N-trifluoroacetyl-L-thyronine ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 72 percent / di-isopropylamine, butyl-lithium / hexane; tetrahydrofuran / -70 deg C, 1.25 h, 0 deg C

2: 67 percent / butyl-lithium, 2.) water / hexane; tetrahydrofuran / -70 deg C, 0.5 h, -65 deg C

3: pyridine / 100 °C

4: 75 percent / H₂ / 10percent Pd/C, 10 M HCl / acetic acid; H₂O / 1.5 h / 2585.7 Torr

5: 37 percent / methanesulphonyl chloride / pyridine / 1.17 h / Heating

6: H₂ / 10percent Pd/C / acetic acid / 1 h / 2585.7 Torr

7: 1.) sulphuric acid, sodium nitrite, 2.) potassium iodide,iodine, urea / 1.) water, -10 deg C, 2.) chloroform, water, RT, 1-2 h

With pyridine; n-butyllithium; sulfuric acid; water; hydrogen; iodine; methanesulfonyl chloride; diisopropylamine; urea; potassium iodide; sodium nitrite; hydrogenchloride; palladium on activated charcoal; In tetrahydrofuran; pyridine; hexane; water; acetic acid;
DOI:10.1039/P19880003085

Reference yield:

: 120130-12-3
4-methoxy-3-<(2-methoxypyridin-4-yl)methyl>phenol

: 120130-22-5
3,5-di-iodo-5'-<(2-methoxypyridin-4-yl)methyl>-4'-O-methyl-N-trifluoroacetyl-L-thyronine ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 37 percent / methanesulphonyl chloride / pyridine / 1.17 h / Heating

2: H₂ / 10percent Pd/C / acetic acid / 1 h / 2585.7 Torr

3: 1.) sulphuric acid, sodium nitrite, 2.) potassium iodide,iodine, urea / 1.) water, -10 deg C, 2.) chloroform, water, RT, 1-2 h

With sulfuric acid; hydrogen; iodine; methanesulfonyl chloride; urea; potassium iodide; sodium nitrite; palladium on activated charcoal; In pyridine; acetic acid;
DOI:10.1039/P19880003085