((4-((3,5-di-tert-butyl-4-methoxyphenyl)ethynyl)phenyl)ethynyl)trimethylsilane

Base Information

• Chemical Name: ((4-((3,5-di-tert-butyl-4-methoxyphenyl)ethynyl)phenyl)ethynyl)trimethylsilane
• CAS No.: 1418130-50-3
• Molecular Formula: C₂₈H₃₆OSi
• Molecular Weight: 416.679
• Mol file: 1418130-50-3.mol

Synonyms:((4-((3,5-di-tert-butyl-4-methoxyphenyl)ethynyl)phenyl)ethynyl)trimethylsilane

Chemical Property of ((4-((3,5-di-tert-butyl-4-methoxyphenyl)ethynyl)phenyl)ethynyl)trimethylsilane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((4-((3,5-di-tert-butyl-4-methoxyphenyl)ethynyl)phenyl)ethynyl)trimethylsilane

There total 2 articles about ((4-((3,5-di-tert-butyl-4-methoxyphenyl)ethynyl)phenyl)ethynyl)trimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3-di-tert-butyl-5-ethynyl-2-methoxy-benzene (345966-18-9) + 1-iodo-4-(trimethylsilylethynyl)benzene (134856-58-9) → ((4-((3,5-di-tert-butyl-4-methoxyphenyl)ethynyl)phenyl)ethynyl)trimethylsilane (1418130-50-3)

Guidance literature:

With copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; triethylamine; In tetrahydrofuran; for 72h; Inert atmosphere;

DOI:10.1016/j.tet.2012.11.063

Reference yield:

2,6-di-tert-butyl-anisole (1516-95-6) → ((4-((3,5-di-tert-butyl-4-methoxyphenyl)ethynyl)phenyl)ethynyl)trimethylsilane (1418130-50-3)

Guidance literature:

Multi-step reaction with 3 steps

1: Iodine monochloride / dichloromethane / 1 h / 0 °C

2: sodium hydride; trans-bis(triphenylphosphine)palladium dichloride; triethylamine / tetrahydrofuran / 48 h / Sealed tube

3: trans-bis(triphenylphosphine)palladium dichloride; triethylamine; copper(l) iodide / tetrahydrofuran / 72 h / Inert atmosphere

With copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; Iodine monochloride; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; 3: |Sonogashira Cross-Coupling;

DOI:10.1016/j.tet.2012.11.063

Reference yield:

((4-((3,5-di-tert-butyl-4-methoxyphenyl)ethynyl)phenyl)ethynyl)trimethylsilane (1418130-50-3) → 1,3-di-tert-butyl-5-((4-ethynylphenyl)ethynyl)-2-methoxybenzene (1418130-51-4)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 2h;

DOI:10.1016/j.tet.2012.11.063

upstream raw materials:

2,6-di-tert-butyl-anisole

1,3-di-tert-butyl-5-ethynyl-2-methoxy-benzene

1-iodo-4-(trimethylsilylethynyl)benzene

Downstream raw materials:

1,3-di-tert-butyl-5-((4-ethynylphenyl)ethynyl)-2-methoxybenzene

1,3-di-tert-butyl-5-((4-((4-((4-iodophenyl)ethynyl)phenyl)ethynyl)phenyl)ethynyl)-2-methoxybenzene

C₆₆H₆₂O₂

1,3-di-tert-butyl-5-((4-((4-((4-((4-iodophenyl)ethynyl)phenyl)ethynyl)phenyl)ethynyl)phenyl)ethynyl)-2-methoxybenzene