(2R,3S)-2-benzyloxycarbonyl[N-(toluene-4-thio)amino]-3-trifluoroacetoxy-2-trifluoromethylbutyric acid methyl ester

Base Information

Chemical Name:(2R,3S)-2-benzyloxycarbonyl[N-(toluene-4-thio)amino]-3-trifluoroacetoxy-2-trifluoromethylbutyric acid methyl ester
CAS No.:276863-00-4
Molecular Formula:C₂₃H₂₁F₆NO₆S
Molecular Weight:553.479
Hs Code.:

Synonyms:(2R,3S)-2-benzyloxycarbonyl[N-(toluene-4-thio)amino]-3-trifluoroacetoxy-2-trifluoromethylbutyric acid methyl ester

Suppliers and Price of (2R,3S)-2-benzyloxycarbonyl[N-(toluene-4-thio)amino]-3-trifluoroacetoxy-2-trifluoromethylbutyric acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3S)-2-benzyloxycarbonyl[N-(toluene-4-thio)amino]-3-trifluoroacetoxy-2-trifluoromethylbutyric acid methyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2R,3S)-2-benzyloxycarbonyl[N-(toluene-4-thio)amino]-3-trifluoroacetoxy-2-trifluoromethylbutyric acid methyl ester

There total 1 articles about (2R,3S)-2-benzyloxycarbonyl[N-(toluene-4-thio)amino]-3-trifluoroacetoxy-2-trifluoromethylbutyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 407-25-0
trifluoroacetic anhydride

: 182699-12-3
(R_S,2R,3R)-2-benzyloxycarbonylamino-3-(toluene-4-sulfinyl)-2-trifluoromethylbutyric acid methyl ester

: 276863-00-4
(2R,3S)-2-benzyloxycarbonyl[N-(toluene-4-thio)amino]-3-trifluoroacetoxy-2-trifluoromethylbutyric acid methyl ester

Guidance literature:: With 2,4,6-trimethyl-pyridine; In acetonitrile; at 0 - 20 ℃; for 0.666667h;
DOI:10.1021/jo991534p

Reference yield:

: 276863-00-4
(2R,3S)-2-benzyloxycarbonyl[N-(toluene-4-thio)amino]-3-trifluoroacetoxy-2-trifluoromethylbutyric acid methyl ester

: (2R,3S)-2-benzyloxycarbonylamino-3-hydroxy-2-trifluoromethylbutyric acid methyl ester

: 129398-25-0
2-benzyloxycarbonylamino-2-trifluoromethylbut-3-enoic acid methyl ester

: 2-benzyloxycarbonyl[N-(toluene-4-thio)amino]-2-trifluoromethylbut-3-enoic acid methyl ester

Guidance literature:: With sodium tetrahydroborate; In water; acetonitrile; at 0 - 20 ℃; for 1.5h;
DOI:10.1021/jo991534p

Reference yield:

: 276863-00-4
(2R,3S)-2-benzyloxycarbonyl[N-(toluene-4-thio)amino]-3-trifluoroacetoxy-2-trifluoromethylbutyric acid methyl ester

: (1S,2R)-4-bromobenzoic acid 2-benzyloxycarbonylamino-3,3,3-trifluoro-2-methoxycarbonyl-1-methylpropyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: NaBH₄ / acetonitrile; H₂O / 1.5 h / 0 - 20 °C

2: 94 percent / Et₃N; DMAP / CH₂Cl₂ / 0.75 h

With dmap; sodium tetrahydroborate; triethylamine; In dichloromethane; water; acetonitrile; 1: Reduction / 2: Acylation;
DOI:10.1021/jo991534p