Benzyloxycarbonylamino-phenyl-acetic acid 2,5-dimethyl-cyclopentyl ester

Base Information

• Chemical Name: Benzyloxycarbonylamino-phenyl-acetic acid 2,5-dimethyl-cyclopentyl ester
• CAS No.: 124441-57-2
• Molecular Formula: C₂₃H₂₇NO₄
• Molecular Weight: 381.472

Synonyms:Benzyloxycarbonylamino-phenyl-acetic acid 2,5-dimethyl-cyclopentyl ester

Chemical Property of Benzyloxycarbonylamino-phenyl-acetic acid 2,5-dimethyl-cyclopentyl ester

Chemical Property:

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Technology Process of Benzyloxycarbonylamino-phenyl-acetic acid 2,5-dimethyl-cyclopentyl ester

There total 3 articles about Benzyloxycarbonylamino-phenyl-acetic acid 2,5-dimethyl-cyclopentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-phenylglycine (875-74-1) → Benzyloxycarbonylamino-phenyl-acetic acid 2,5-dimethyl-cyclopentyl ester (124441-57-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 49 percent / 4N NaOH / H₂O / 0.17 h

2: dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / CH₂Cl₂ / 1.) -78 deg C, 0.5 h, 2.) -23 deg C

With dmap; sodium hydroxide; dicyclohexyl-carbodiimide; In dichloromethane; water;

DOI:10.1021/jm00165a027

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → Benzyloxycarbonylamino-phenyl-acetic acid 2,5-dimethyl-cyclopentyl ester (124441-57-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 49 percent / 4N NaOH / H₂O / 0.17 h

2: dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / CH₂Cl₂ / 1.) -78 deg C, 0.5 h, 2.) -23 deg C

With dmap; sodium hydroxide; dicyclohexyl-carbodiimide; In dichloromethane; water;

DOI:10.1021/jm00165a027

Reference yield:

Z-D-phenylglycine (17609-52-8) + 2,5-dimethylcyclopentanol (22417-55-6) → Benzyloxycarbonylamino-phenyl-acetic acid 2,5-dimethyl-cyclopentyl ester (124441-57-2)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; 1.) -78 deg C, 0.5 h, 2.) -23 deg C;

DOI:10.1021/jm00165a027

upstream raw materials:

Z-D-phenylglycine

2,5-dimethylcyclopentanol

(R)-phenylglycine

benzyl chloroformate

Downstream raw materials:

Amino-phenyl-acetic acid 2,5-dimethyl-cyclopentyl ester

(S)-3-Benzyloxycarbonylamino-N-[(2,5-dimethyl-cyclopentyloxycarbonyl)-phenyl-methyl]-succinamic acid benzyl ester

(S)-3-Amino-N-[(2,5-dimethyl-cyclopentyloxycarbonyl)-phenyl-methyl]-succinamic acid

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