L-isoseryl-L-phenylalanyl-L-leucine benzyl ester hydrochloride

Base Information

Chemical Name:L-isoseryl-L-phenylalanyl-L-leucine benzyl ester hydrochloride
CAS No.:1365292-48-3
Molecular Formula:C₂₅H₃₃N₃O₅*ClH
Molecular Weight:492.015
Hs Code.:

Synonyms:L-isoseryl-L-phenylalanyl-L-leucine benzyl ester hydrochloride

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Chemical Property of L-isoseryl-L-phenylalanyl-L-leucine benzyl ester hydrochloride

Chemical Property:

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Technology Process of L-isoseryl-L-phenylalanyl-L-leucine benzyl ester hydrochloride

There total 8 articles about L-isoseryl-L-phenylalanyl-L-leucine benzyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.1%

: C₃₀H₄₁N₃O₇

: 1365292-48-3
L-isoseryl-L-phenylalanyl-L-leucine benzyl ester hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 0 - 20 ℃; for 7h;
DOI:10.3109/14756361003698147

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 1365292-48-3
L-isoseryl-L-phenylalanyl-L-leucine benzyl ester hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide / methanol

2: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 13 h / 0 - 20 °C

3: hydrogenchloride / ethyl acetate / 7 h / 0 - 20 °C

4: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 13 h / 0 - 20 °C

5: hydrogenchloride / ethyl acetate / 7 h / 0 - 20 °C

With hydrogenchloride; dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In methanol; dichloromethane; ethyl acetate;
DOI:10.3109/14756361003698147

Reference yield:

: 61-90-5,21675-61-6,25248-98-0,70-45-1
L-leucine

: 1365292-48-3
L-isoseryl-L-phenylalanyl-L-leucine benzyl ester hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydroxide / methanol

2: tetra-(n-butyl)ammonium iodide; potassium carbonate; potassium iodide / acetone

3: hydrogenchloride / ethyl acetate

4: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 13 h / 0 - 20 °C

5: hydrogenchloride / ethyl acetate / 7 h / 0 - 20 °C

6: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 13 h / 0 - 20 °C

7: hydrogenchloride / ethyl acetate / 7 h / 0 - 20 °C

With hydrogenchloride; dmap; tetra-(n-butyl)ammonium iodide; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium iodide; sodium hydroxide; In methanol; dichloromethane; ethyl acetate; acetone;
DOI:10.3109/14756361003698147