Technology Process of C13H10(2)H2ClF3N2O
There total 8 articles about C13H10(2)H2ClF3N2O which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
Grubbs catalyst first generation;
In
dichloromethane;
for 0.75h;
Inert atmosphere;
Reflux;
DOI:10.1021/ol103170y
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: trifluoroacetic acid / chloroform; water / 2 h / 20 °C
2.1: n-butyllithium / tetrahydrofuran; hexane / 1.5 h / 0 °C / Inert atmosphere
2.2: 2.25 h / -10 - 20 °C / Inert atmosphere; Reflux
2.3: 17.5 h / 20 °C
3.1: Grubbs catalyst first generation / dichloromethane / 0.75 h / Inert atmosphere; Reflux
With
Grubbs catalyst first generation; n-butyllithium; trifluoroacetic acid;
In
tetrahydrofuran; hexane; dichloromethane; chloroform; water;
2.1: Wittig-Staudinger reaction / 2.2: Wittig-Staudinger reaction;
DOI:10.1021/ol103170y
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 1.5 h / 0 °C / Inert atmosphere
1.2: 2.25 h / -10 - 20 °C / Inert atmosphere; Reflux
1.3: 17.5 h / 20 °C
2.1: Grubbs catalyst first generation / dichloromethane / 0.75 h / Inert atmosphere; Reflux
With
Grubbs catalyst first generation; n-butyllithium;
In
tetrahydrofuran; hexane; dichloromethane;
1.1: Wittig-Staudinger reaction / 1.2: Wittig-Staudinger reaction;
DOI:10.1021/ol103170y