(3'aα,5'α,6'aα)-hexahydro-5,5-dimethylspiro[1,3-dioxane-2,2'(1'H)-pentalen]-5'-yl-4-nitrobenzoate

Base Information

Chemical Name:(3'aα,5'α,6'aα)-hexahydro-5,5-dimethylspiro[1,3-dioxane-2,2'(1'H)-pentalen]-5'-yl-4-nitrobenzoate
CAS No.:481046-16-6
Molecular Formula:C₂₀H₂₅NO₆
Molecular Weight:375.422
Hs Code.:

Synonyms:(3'aα,5'α,6'aα)-hexahydro-5,5-dimethylspiro[1,3-dioxane-2,2'(1'H)-pentalen]-5'-yl-4-nitrobenzoate

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Chemical Property of (3'aα,5'α,6'aα)-hexahydro-5,5-dimethylspiro[1,3-dioxane-2,2'(1'H)-pentalen]-5'-yl-4-nitrobenzoate

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Technology Process of (3'aα,5'α,6'aα)-hexahydro-5,5-dimethylspiro[1,3-dioxane-2,2'(1'H)-pentalen]-5'-yl-4-nitrobenzoate

There total 2 articles about (3'aα,5'α,6'aα)-hexahydro-5,5-dimethylspiro[1,3-dioxane-2,2'(1'H)-pentalen]-5'-yl-4-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 92007-39-1
(3'aα,5'β,6'aα)-hexahydro-5,5-dimethylspiro[1,3-dioxane-2,2'(1'H)-pentalen]-5'-ol

: 62-23-7
4-nitro-benzoic acid

: 481046-16-6
(3'aα,5'α,6'aα)-hexahydro-5,5-dimethylspiro[1,3-dioxane-2,2'(1'H)-pentalen]-5'-yl-4-nitrobenzoate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In diethyl ether; at 20 ℃; for 14h;
DOI:10.1002/ejoc.200300023

Reference yield:

: 112755-94-9,92007-37-9
(3a'R,6a'S)-5,5-dimethyltetrahydro-1'H-spiro[1,3-dioxane-2,2'-pentalen]-5'(3'H)-one

: 481046-16-6
(3'aα,5'α,6'aα)-hexahydro-5,5-dimethylspiro[1,3-dioxane-2,2'(1'H)-pentalen]-5'-yl-4-nitrobenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / NaBH₄ / methanol / 4 h / -2 - 0 °C

2: 77 percent / triphenylphosphane; DEAD / diethyl ether / 14 h / 20 °C

With sodium tetrahydroborate; triphenylphosphine; diethylazodicarboxylate; In methanol; diethyl ether;
DOI:10.1002/ejoc.200300023

Reference yield:

: 481046-16-6
(3'aα,5'α,6'aα)-hexahydro-5,5-dimethylspiro[1,3-dioxane-2,2'(1'H)-pentalen]-5'-yl-4-nitrobenzoate

: 92007-41-5,100668-54-0
cis-(1',3'a,6',6'a)-tetrahydro-5,5-dimethylspiro[1,3-dioxane-2,2'(1'H)-pentalen]-5'-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / potassium hydroxide / methanol; H₂O / 15 h / 40 °C

2: 10 percent / triphenylphosphane; N-chlorosuccinimide / tetrahydrofuran / 1.5 h / 20 °C

With potassium hydroxide; N-chloro-succinimide; triphenylphosphine; In tetrahydrofuran; methanol; water;
DOI:10.1002/ejoc.200300023