(3-{2-[(S)-1-(2-fluorophenyl)ethylamino]-6,6-dimethyl-4,4-dioxo-5,6-dihydro-4H-4lambda6-[1,4,3]-oxathiazin-5-yl}phenyl)-(4-methylpiperazin-1-yl)methanone

Base Information

Chemical Name:(3-{2-[(S)-1-(2-fluorophenyl)ethylamino]-6,6-dimethyl-4,4-dioxo-5,6-dihydro-4H-4lambda6-[1,4,3]-oxathiazin-5-yl}phenyl)-(4-methylpiperazin-1-yl)methanone
CAS No.:1397750-05-8
Molecular Formula:C₂₅H₃₁FN₄O₄S
Molecular Weight:502.61
Hs Code.:

(3-{2-[(S)-1-(2-fluorophenyl)ethylamino]-6,6-dimethyl-4,4-dioxo-5,6-dihydro-4H-4lambda6-[1,4,3]-oxathiazin-5-yl}phenyl)-(4-methylpiperazin-1-yl)methanone

Synonyms:(3-{2-[(S)-1-(2-fluorophenyl)ethylamino]-6,6-dimethyl-4,4-dioxo-5,6-dihydro-4H-4lambda6-[1,4,3]-oxathiazin-5-yl}phenyl)-(4-methylpiperazin-1-yl)methanone

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Chemical Property of (3-{2-[(S)-1-(2-fluorophenyl)ethylamino]-6,6-dimethyl-4,4-dioxo-5,6-dihydro-4H-4lambda6-[1,4,3]-oxathiazin-5-yl}phenyl)-(4-methylpiperazin-1-yl)methanone

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Technology Process of (3-{2-[(S)-1-(2-fluorophenyl)ethylamino]-6,6-dimethyl-4,4-dioxo-5,6-dihydro-4H-4lambda6-[1,4,3]-oxathiazin-5-yl}phenyl)-(4-methylpiperazin-1-yl)methanone

There total 6 articles about (3-{2-[(S)-1-(2-fluorophenyl)ethylamino]-6,6-dimethyl-4,4-dioxo-5,6-dihydro-4H-4lambda6-[1,4,3]-oxathiazin-5-yl}phenyl)-(4-methylpiperazin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1397715-12-6
3-{2-[(S)-1-(2-fluorophenyl)ethylamino]-6,6-dimethyl-4,4-dioxo-5,6-dihydro-4H-4lambda6-[1,4,3]-oxathiazin-5-yl}benzoic acid

: 1397750-05-8
(3-{2-[(S)-1-(2-fluorophenyl)ethylamino]-6,6-dimethyl-4,4-dioxo-5,6-dihydro-4H-4lambda6-[1,4,3]-oxathiazin-5-yl}phenyl)-(4-methylpiperazin-1-yl)methanone

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h;

Reference yield:

: 1397715-44-4
3-[(2,4-dimethoxybenzylsulfamoyl)methyl]benzoic acid methyl ester

: 1397750-05-8
(3-{2-[(S)-1-(2-fluorophenyl)ethylamino]-6,6-dimethyl-4,4-dioxo-5,6-dihydro-4H-4lambda6-[1,4,3]-oxathiazin-5-yl}phenyl)-(4-methylpiperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / water; methanol / 16 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran / 0.17 h / -78 °C

2.2: 0.5 h / -78 °C

2.3: 2 h

3.1: acetic acid / 16 h / 85 °C

4.1: dichloromethane / 4 h / Inert atmosphere

5.1: sulfuric acid / water; 1,4-dioxane / 16 h / 100 °C

6.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1.5 h / 20 °C

With n-butyllithium; sulfuric acid; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1397715-10-4
3-(2-methoxy-6,6-dimethyl-4,4-dioxo-5,6-dihydro-4H-4lambda6-[1,4,3]-oxathiazin-5-yl)benzoic acid methyl ester

: 1397750-05-8
(3-{2-[(S)-1-(2-fluorophenyl)ethylamino]-6,6-dimethyl-4,4-dioxo-5,6-dihydro-4H-4lambda6-[1,4,3]-oxathiazin-5-yl}phenyl)-(4-methylpiperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 4 h / Inert atmosphere

2: sulfuric acid / water; 1,4-dioxane / 16 h / 100 °C

3: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1.5 h / 20 °C

With sulfuric acid; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;