(3-{Benzyloxy-[(1S,2R,3R,4S,5S,6R)-2,6-bis-benzyloxymethoxy-3,4,5-tris-(4-methoxy-benzyloxy)-cyclohexyloxy]-phosphoryloxy}-propyl)-carbamic acid benzyl ester

Base Information

Chemical Name:(3-{Benzyloxy-[(1S,2R,3R,4S,5S,6R)-2,6-bis-benzyloxymethoxy-3,4,5-tris-(4-methoxy-benzyloxy)-cyclohexyloxy]-phosphoryloxy}-propyl)-carbamic acid benzyl ester
CAS No.:137897-33-7
Molecular Formula:C₆₄H₇₂NO₁₆P
Molecular Weight:1142.25
Hs Code.:

(3-{Benzyloxy-[(1S,2R,3R,4S,5S,6R)-2,6-bis-benzyloxymethoxy-3,4,5-tris-(4-methoxy-benzyloxy)-cyclohexyloxy]-phosphoryloxy}-propyl)-carbamic acid benzyl ester

Synonyms:(3-{Benzyloxy-[(1S,2R,3R,4S,5S,6R)-2,6-bis-benzyloxymethoxy-3,4,5-tris-(4-methoxy-benzyloxy)-cyclohexyloxy]-phosphoryloxy}-propyl)-carbamic acid benzyl ester

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Chemical Property of (3-{Benzyloxy-[(1S,2R,3R,4S,5S,6R)-2,6-bis-benzyloxymethoxy-3,4,5-tris-(4-methoxy-benzyloxy)-cyclohexyloxy]-phosphoryloxy}-propyl)-carbamic acid benzyl ester

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Technology Process of (3-{Benzyloxy-[(1S,2R,3R,4S,5S,6R)-2,6-bis-benzyloxymethoxy-3,4,5-tris-(4-methoxy-benzyloxy)-cyclohexyloxy]-phosphoryloxy}-propyl)-carbamic acid benzyl ester

There total 9 articles about (3-{Benzyloxy-[(1S,2R,3R,4S,5S,6R)-2,6-bis-benzyloxymethoxy-3,4,5-tris-(4-methoxy-benzyloxy)-cyclohexyloxy]-phosphoryloxy}-propyl)-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (3-{Benzyloxy-[(1S,2R,3R,4S,5S,6R)-2,6-bis-benzyloxymethoxy-3,4,5-tris-(4-methoxy-benzyloxy)-cyclohexyloxy]-phosphanyloxy}-propyl)-carbamic acid benzyl ester

: 137897-33-7
(3-{Benzyloxy-[(1S,2R,3R,4S,5S,6R)-2,6-bis-benzyloxymethoxy-3,4,5-tris-(4-methoxy-benzyloxy)-cyclohexyloxy]-phosphoryloxy}-propyl)-carbamic acid benzyl ester

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at -48 - 0 ℃; for 0.3h; Yield given;
DOI:10.1021/ja00026a043

Reference yield:

: 137897-35-9
(2S,3S,4S,5R,6S)-6-Methoxy-3,4,5-tris-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-carbaldehyde

: 137897-33-7
(3-{Benzyloxy-[(1S,2R,3R,4S,5S,6R)-2,6-bis-benzyloxymethoxy-3,4,5-tris-(4-methoxy-benzyloxy)-cyclohexyloxy]-phosphoryloxy}-propyl)-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: K₂CO₃ / acetonitrile / 8 h / 80 °C

2: 1.) Hg(OAc)2, 2.) NaCl / 1.) acetone, H₂O, RT, 30 min, 2.) acetone, H₂O, RT, 24 h

3: NaBH(OAc)3, HOAc / acetonitrile / 0.5 h / Ambient temperature

4: 69 percent / Bu₄NBr, H⁽¹⁺⁾ sponge / acetonitrile / 21 h / 20 - 55 °C

5: 95 percent / NaOH / methanol / 2 h / Heating

6: tetrazole / CH₂Cl₂ / 3 h / Ambient temperature

7: MCPBA / CH₂Cl₂ / 0.3 h / -48 - 0 °C

With 1H-tetrazole; sodium hydroxide; mercury(II) diacetate; tetrabutylammomium bromide; hydrogen cation; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; 3-chloro-benzenecarboperoxoic acid; sodium chloride; In methanol; dichloromethane; acetonitrile;
DOI:10.1021/ja00026a043

Reference yield:

: 137915-48-1
methyl 2,3,4,-tri-O-(4-methoxybenzyl)-α-D-glucopyranoside

: 137897-33-7
(3-{Benzyloxy-[(1S,2R,3R,4S,5S,6R)-2,6-bis-benzyloxymethoxy-3,4,5-tris-(4-methoxy-benzyloxy)-cyclohexyloxy]-phosphoryloxy}-propyl)-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: oxalyl chloride, DMSO, Et₃N / CH₂Cl₂ / -78 - 20 °C

2: K₂CO₃ / acetonitrile / 8 h / 80 °C

3: 1.) Hg(OAc)2, 2.) NaCl / 1.) acetone, H₂O, RT, 30 min, 2.) acetone, H₂O, RT, 24 h

4: NaBH(OAc)3, HOAc / acetonitrile / 0.5 h / Ambient temperature

5: 69 percent / Bu₄NBr, H⁽¹⁺⁾ sponge / acetonitrile / 21 h / 20 - 55 °C

6: 95 percent / NaOH / methanol / 2 h / Heating

7: tetrazole / CH₂Cl₂ / 3 h / Ambient temperature

8: MCPBA / CH₂Cl₂ / 0.3 h / -48 - 0 °C

With 1H-tetrazole; sodium hydroxide; oxalyl dichloride; mercury(II) diacetate; tetrabutylammomium bromide; hydrogen cation; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium chloride; In methanol; dichloromethane; acetonitrile;
DOI:10.1021/ja00026a043