N-[2-{[(3-cyanophenyl)carbamoyl]amino}-1-(3-ethoxypropyl)-1H-benzimidazol-5-yl]-N-methylpropanamide

Base Information

Chemical Name:N-[2-{[(3-cyanophenyl)carbamoyl]amino}-1-(3-ethoxypropyl)-1H-benzimidazol-5-yl]-N-methylpropanamide
CAS No.:1424293-15-1
Molecular Formula:C₂₄H₂₈N₆O₃
Molecular Weight:448.525
Hs Code.:

Synonyms:N-[2-{[(3-cyanophenyl)carbamoyl]amino}-1-(3-ethoxypropyl)-1H-benzimidazol-5-yl]-N-methylpropanamide

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Chemical Property of N-[2-{[(3-cyanophenyl)carbamoyl]amino}-1-(3-ethoxypropyl)-1H-benzimidazol-5-yl]-N-methylpropanamide

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Technology Process of N-[2-{[(3-cyanophenyl)carbamoyl]amino}-1-(3-ethoxypropyl)-1H-benzimidazol-5-yl]-N-methylpropanamide

There total 5 articles about N-[2-{[(3-cyanophenyl)carbamoyl]amino}-1-(3-ethoxypropyl)-1H-benzimidazol-5-yl]-N-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1424297-65-3
N-[2-amino-1-(3-ethoxypropyl)-1H-benzimidazol-5-yl]-N-methylpropanamide

: 50699-53-1
phenyl N-(3-cyanophenyl)carbamate

: 1424293-15-1
N-[2-{[(3-cyanophenyl)carbamoyl]amino}-1-(3-ethoxypropyl)-1H-benzimidazol-5-yl]-N-methylpropanamide

Guidance literature:: N-[2-amino-1-(3-ethoxypropyl)-1H-benzimidazol-5-yl]-N-methylpropanamide; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

phenyl N-(3-cyanophenyl)carbamate; In N,N-dimethyl-formamide;

Reference yield:

: N-(4-fluoro-3-nitrophenyl)-N-methylpropanamide

: 1424293-15-1
N-[2-{[(3-cyanophenyl)carbamoyl]amino}-1-(3-ethoxypropyl)-1H-benzimidazol-5-yl]-N-methylpropanamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 80 °C

2: palladium 10% on activated carbon; ammonium formate / ethanol / 3 h / 20 °C

3: ethanol

4: triethylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

With palladium 10% on activated carbon; ammonium formate; triethylamine; N-ethyl-N,N-diisopropylamine; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 152666-75-6
N-(4-fluoro-3-nitrophenyl)propanamide

: 1424293-15-1
N-[2-{[(3-cyanophenyl)carbamoyl]amino}-1-(3-ethoxypropyl)-1H-benzimidazol-5-yl]-N-methylpropanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / dimethyl sulfoxide / 0.5 h / 20 °C

1.2: 20 °C

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 80 °C

3.1: palladium 10% on activated carbon; ammonium formate / ethanol / 3 h / 20 °C

4.1: ethanol

5.1: triethylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

With palladium 10% on activated carbon; ammonium formate; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;