N-(2-(3-aminopropoxy)-4-(4-(2-(3-hydroxyphenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-1,2,3,6-tetrahydropyridine-1-carbonyl)phenyl)acrylamide trifluoroacetate

Base Information

Chemical Name:N-(2-(3-aminopropoxy)-4-(4-(2-(3-hydroxyphenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-1,2,3,6-tetrahydropyridine-1-carbonyl)phenyl)acrylamide trifluoroacetate
CAS No.:1276109-94-4
Molecular Formula:C₂HF₃O₂*C₃₄H₃₆N₆O₅S
Molecular Weight:754.787
Hs Code.:

N-(2-(3-aminopropoxy)-4-(4-(2-(3-hydroxyphenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-1,2,3,6-tetrahydropyridine-1-carbonyl)phenyl)acrylamide trifluoroacetate

Synonyms:N-(2-(3-aminopropoxy)-4-(4-(2-(3-hydroxyphenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-1,2,3,6-tetrahydropyridine-1-carbonyl)phenyl)acrylamide trifluoroacetate

Suppliers and Price of N-(2-(3-aminopropoxy)-4-(4-(2-(3-hydroxyphenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-1,2,3,6-tetrahydropyridine-1-carbonyl)phenyl)acrylamide trifluoroacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(2-(3-aminopropoxy)-4-(4-(2-(3-hydroxyphenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-1,2,3,6-tetrahydropyridine-1-carbonyl)phenyl)acrylamide trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(2-(3-aminopropoxy)-4-(4-(2-(3-hydroxyphenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-1,2,3,6-tetrahydropyridine-1-carbonyl)phenyl)acrylamide trifluoroacetate

There total 12 articles about N-(2-(3-aminopropoxy)-4-(4-(2-(3-hydroxyphenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-1,2,3,6-tetrahydropyridine-1-carbonyl)phenyl)acrylamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1276109-92-2
tert-butyl 3-(2-acrylamido-5-(4-(2-(3-hydroxyphenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-1,2,3,6-tetrahydropyridine-1-carbonyl)phenoxy)propylcarbamate

: 76-05-1
trifluoroacetic acid

: 1276109-94-4
N-(2-(3-aminopropoxy)-4-(4-(2-(3-hydroxyphenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-1,2,3,6-tetrahydropyridine-1-carbonyl)phenyl)acrylamide trifluoroacetate

Guidance literature:: In dichloromethane;

Reference yield:

: 713-52-0
methyl 3-hydroxy-4-nitrobenzoate

: 1276109-94-4
N-(2-(3-aminopropoxy)-4-(4-(2-(3-hydroxyphenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-1,2,3,6-tetrahydropyridine-1-carbonyl)phenyl)acrylamide trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2: hydrogen / palladium 10% on activated carbon / methanol

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / -20 °C

4: sodium hydroxide; water / 1,4-dioxane / 20 °C

5: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl acetamide

6: dichloromethane

With di-isopropyl azodicarboxylate; water; hydrogen; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl acetamide; 1: Mitsunobu reaction;

Reference yield:

: 16234-14-3
2,4-dichlorothieno[3,2-d]pyrimidine

: 1276109-94-4
N-(2-(3-aminopropoxy)-4-(4-(2-(3-hydroxyphenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-1,2,3,6-tetrahydropyridine-1-carbonyl)phenyl)acrylamide trifluoroacetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: methanol / 1 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran / 2.5 h / -78 - -40 °C

2.2: 8 h / -78 - 20 °C

3.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / toluene; ethanol; water / 3 h / 40 °C / Inert atmosphere

4.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / toluene; ethanol; water / 3 h / 130 °C / Inert atmosphere

5.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 1 h

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl acetamide

7.1: dichloromethane

With hydrogenchloride; n-butyllithium; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl acetamide; water; toluene; 3.1: Suzuki Coupling / 4.1: Suzuki Coupling;