5-[(3-Hydroxyphenyl)methyl]oxolan-2-one

Base Information

Chemical Name:5-[(3-Hydroxyphenyl)methyl]oxolan-2-one
CAS No.:21618-91-7
Molecular Formula:C₁₁H₁₂O₃
Molecular Weight:192.214
Hs Code.:
European Community (EC) Number:840-163-2
Nikkaji Number:J2.843.838I
Wikidata:Q59900676

Synonyms:5-[(3-hydroxyphenyl)methyl]oxolan-2-one;21618-91-7;NIOSH/LU5167400;SCHEMBL18973360;AKOS026726636;5-(3'-hydroxyphenyl)-gamma-valerolactone;LS-70521;Tetrahydro-5-(3-hydroxybenzyl)-2-furanone;CS-0222979;LU51674000;2-Furanone, tetrahydro-5-(3-hydroxybenzyl)-;EN300-113446;4-Hydroxy-5-(3-hydroxyphenyl)pentanoic-1,4-lactone;Q59900676;5-(3-Hydroxyphenyl)-4-hydroxyvaleric acid gamma-lactone;Z1342095237

Suppliers and Price of 5-[(3-Hydroxyphenyl)methyl]oxolan-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 5-[(3-Hydroxyphenyl)methyl]oxolan-2-one

Chemical Property:

XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:192.078644241
Heavy Atom Count:14
Complexity:215

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CC(=O)OC1CC2=CC(=CC=C2)O

Technology Process of 5-[(3-Hydroxyphenyl)methyl]oxolan-2-one

There total 7 articles about 5-[(3-Hydroxyphenyl)methyl]oxolan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: C₁₈H₁₈O₃

: 21618-91-7
5-(3′-hydroxyphenyl)-γ-valerolactone

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; Inert atmosphere;

Reference yield:

: 100-83-4
meta-hydroxybenzaldehyde

: 21618-91-7
5-(3′-hydroxyphenyl)-γ-valerolactone

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / acetonitrile / 20 °C

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.33 h / -20 °C / Inert atmosphere

2.2: -65 - 20 °C

3.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 48 h / 20 °C

4.1: 3-quinuclidinol; N-Bromosuccinimide; Eudesmic acid / toluene / -20 - 20 °C

5.1: tris-(trimethylsilyl)silane; 2,2'-azobis(isobutyronitrile) / toluene / 20 °C / Reflux

6.1: palladium 10% on activated carbon; hydrogen / methanol / Inert atmosphere

With N-Bromosuccinimide; lithium hydroxide monohydrate; 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane; palladium 10% on activated carbon; hydrogen; sodium hexamethyldisilazane; potassium carbonate; 3-quinuclidinol; Eudesmic acid; In tetrahydrofuran; methanol; water; toluene; acetonitrile;

Reference yield:

: C₁₈H₁₈O₃

: 21618-91-7
5-(3′-hydroxyphenyl)-γ-valerolactone

Guidance literature:: Multi-step reaction with 3 steps

1: 3-quinuclidinol; N-Bromosuccinimide; Eudesmic acid / toluene / -20 - 20 °C

2: tris-(trimethylsilyl)silane; 2,2'-azobis(isobutyronitrile) / toluene / 20 °C / Reflux

3: palladium 10% on activated carbon; hydrogen / methanol / Inert atmosphere

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane; palladium 10% on activated carbon; hydrogen; 3-quinuclidinol; Eudesmic acid; In methanol; toluene;