4-(tert-butyl-dimethyl-silanyloxy)-3-(2-hydroxy-6-methyl-phenylamino)-thiobutyric acid S-ethyl ester

Base Information

Chemical Name:4-(tert-butyl-dimethyl-silanyloxy)-3-(2-hydroxy-6-methyl-phenylamino)-thiobutyric acid S-ethyl ester
CAS No.:383418-27-7
Molecular Formula:C₁₉H₃₃NO₃SSi
Molecular Weight:383.627
Hs Code.:

4-(<i>tert</i>-butyl-dimethyl-silanyloxy)-3-(2-hydroxy-6-methyl-phenylamino)-thiobutyric acid <i>S</i>-ethyl ester

Synonyms:4-(tert-butyl-dimethyl-silanyloxy)-3-(2-hydroxy-6-methyl-phenylamino)-thiobutyric acid S-ethyl ester

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Chemical Property of 4-(tert-butyl-dimethyl-silanyloxy)-3-(2-hydroxy-6-methyl-phenylamino)-thiobutyric acid S-ethyl ester

Chemical Property:

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Technology Process of 4-(tert-butyl-dimethyl-silanyloxy)-3-(2-hydroxy-6-methyl-phenylamino)-thiobutyric acid S-ethyl ester

There total 1 articles about 4-(tert-butyl-dimethyl-silanyloxy)-3-(2-hydroxy-6-methyl-phenylamino)-thiobutyric acid S-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2835-97-4
2-amino-3-methylphenol

: 63584-41-8
1-ethylthio-1-(trimethylsiloxy)ethene

: 102191-92-4
tert-butyldimethylsiloxyacetaldehyde

: 4-(tert-butyl-dimethyl-silanyloxy)-3-(2-hydroxy-6-methyl-phenylamino)-thiobutyric acid S-ethyl ester

: 383418-27-7
4-(tert-butyl-dimethyl-silanyloxy)-3-(2-hydroxy-6-methyl-phenylamino)-thiobutyric acid S-ethyl ester

Guidance literature:: With 1-methyl-1H-imidazole; (R)-6,6'-dibromo-1,1'-binaphth-2-ol; zirconium(IV) tert-butoxide; MS₄A; In dichloromethane; at -45 ℃;
DOI:10.1016/S0040-4039(01)01658-6

Reference yield:

: 383418-27-7
4-(tert-butyl-dimethyl-silanyloxy)-3-(2-hydroxy-6-methyl-phenylamino)-thiobutyric acid S-ethyl ester

: 383418-13-1
dodecanoic acid [1-(tert-butyl-dimethyl-silanyloxymethyl)-3-oxo-3-phenyl-propyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 61 percent / CAN / acetonitrile; H₂O / 0.5 h / 0 °C

2: 81 percent / Et₃N / CH₂Cl₂ / 20 °C

3: 37 percent / tetrahydrofuran / 1 h / -15 °C

With ammonium cerium(IV) nitrate; triethylamine; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1016/S0040-4039(01)01658-6

Reference yield:

: 383418-27-7
4-(tert-butyl-dimethyl-silanyloxy)-3-(2-hydroxy-6-methyl-phenylamino)-thiobutyric acid S-ethyl ester

: Dodecanoic acid [(1R,3S)-1-(tert-butyl-dimethyl-silanyloxymethyl)-3-hydroxy-3-phenyl-propyl]-amide

: 383418-15-3
Dodecanoic acid [(1R,3R)-1-(tert-butyl-dimethyl-silanyloxymethyl)-3-hydroxy-3-phenyl-propyl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium cerium (IV) nitrate / water; acetonitrile / 0 °C

2: triethylamine / dichloromethane / 20 °C

3: tetrahydrofuran / -15 °C

4: L-Selectride / tetrahydrofuran / -78 °C

With ammonium cerium (IV) nitrate; L-Selectride; triethylamine; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1021/ol401101u