ethyl 2-cyano-3-(4-(7-pivaloyl-5-((2-(trimethyl-silyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)phenyl)acrylate

Base Information

Chemical Name:ethyl 2-cyano-3-(4-(7-pivaloyl-5-((2-(trimethyl-silyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)phenyl)acrylate
CAS No.:1413914-00-7
Molecular Formula:C₂₉H₃₇N₅O₄Si
Molecular Weight:547.729
Hs Code.:

Synonyms:ethyl 2-cyano-3-(4-(7-pivaloyl-5-((2-(trimethyl-silyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)phenyl)acrylate

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Chemical Property of ethyl 2-cyano-3-(4-(7-pivaloyl-5-((2-(trimethyl-silyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)phenyl)acrylate

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Technology Process of ethyl 2-cyano-3-(4-(7-pivaloyl-5-((2-(trimethyl-silyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)phenyl)acrylate

There total 6 articles about ethyl 2-cyano-3-(4-(7-pivaloyl-5-((2-(trimethyl-silyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)phenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1413912-54-5
4-(7-pivaloyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-2-ylamino) benzaldehyde

: 105-56-6
ethyl 2-cyanoacetate

: 1413914-00-7
ethyl 2-cyano-3-(4-(7-pivaloyl-5-((2-(trimethyl-silyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)phenyl)acrylate

Guidance literature:: With piperidinyl acetate; In ethanol; water; at 20 - 80 ℃; for 2h;

Reference yield:

: 875781-41-2
5-bromo-3-((trimethylsilyl)ethynyl)pyrazine-2-amine

: 1413914-00-7
ethyl 2-cyano-3-(4-(7-pivaloyl-5-((2-(trimethyl-silyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)phenyl)acrylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium tert-butylate / tetrahydrofuran / 1.83 h / 20 - 65 °C / Inert atmosphere

2.1: diethyl aluminiumcholoride / dichloromethane; hexane / 0.5 h / 0 °C / Inert atmosphere

2.2: 21.17 h / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 0.42 h / 0 °C

3.2: 0.5 h / 0 - 20 °C

4.1: caesium carbonate / toluene / 0.75 h / 20 °C / Sealed tube; Inert atmosphere

4.2: 4 h / 110 °C

5.1: pyridinium chlorochromate / dichloromethane / 2 h / 5 - 20 °C / Inert atmosphere

6.1: piperidinyl acetate / ethanol; water / 2 h / 20 - 80 °C

With piperidinyl acetate; diethyl aluminiumcholoride; potassium tert-butylate; sodium hydride; caesium carbonate; pyridinium chlorochromate; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene; paraffin oil;

Reference yield:

: 875781-43-4
2-bromo-5H-pyrrolo[2,3-b]pyrazine

: 1413914-00-7
ethyl 2-cyano-3-(4-(7-pivaloyl-5-((2-(trimethyl-silyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)phenyl)acrylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: diethyl aluminiumcholoride / dichloromethane; hexane / 0.5 h / 0 °C / Inert atmosphere

1.2: 21.17 h / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 0.42 h / 0 °C

2.2: 0.5 h / 0 - 20 °C

3.1: caesium carbonate / toluene / 0.75 h / 20 °C / Sealed tube; Inert atmosphere

3.2: 4 h / 110 °C

4.1: pyridinium chlorochromate / dichloromethane / 2 h / 5 - 20 °C / Inert atmosphere

5.1: piperidinyl acetate / ethanol; water / 2 h / 20 - 80 °C

With piperidinyl acetate; diethyl aluminiumcholoride; sodium hydride; caesium carbonate; pyridinium chlorochromate; In ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene; paraffin oil;