{2-[5-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-indole-1-carbonyl]-phenyl}-carbamic acid

Base Information

Chemical Name:{2-[5-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-indole-1-carbonyl]-phenyl}-carbamic acid
CAS No.:145303-59-9
Molecular Formula:C₂₇H₂₅N₅O₃
Molecular Weight:467.527
Hs Code.:

Synonyms:{2-[5-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-indole-1-carbonyl]-phenyl}-carbamic acid

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Chemical Property of {2-[5-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-indole-1-carbonyl]-phenyl}-carbamic acid

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Technology Process of {2-[5-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-indole-1-carbonyl]-phenyl}-carbamic acid

There total 5 articles about {2-[5-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-indole-1-carbonyl]-phenyl}-carbamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 118-48-9
isatoic anhydride

: 145303-54-4
3-<(5-indolyl)methyl>-5,7-dimethyl-2-ethyl-3H-imidazo<4,5-b>pyridine

: 145303-59-9
{2-[5-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-indole-1-carbonyl]-phenyl}-carbamic acid

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; for 16h;
DOI:10.1021/jm00078a013

Reference yield:

: 614-96-0
5-methyl-1H-indole

: 145303-59-9
{2-[5-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-indole-1-carbonyl]-phenyl}-carbamic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / 4-(dimethylamino)pyridine, Et₃N / CH₂Cl₂ / 16 h / Ambient temperature

2: 80 percent / N-bromosuccinimide, azoisobutyronitrile / CCl₄ / 4 h / Heating

3: NaH / 1.) DMF, 5 min, 2.) DMF, 2.5 h

4: 100 percent / 2 N aq. NaOH / methanol / 18 h / 60 °C

5: 30 percent / NaH / dimethylformamide / 16 h

With dmap; sodium hydroxide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydride; triethylamine; In methanol; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00078a013

Reference yield:

: 145303-51-1
(5-methyl-1H-indol-1-yl)(phenyl)methanone

: 145303-59-9
{2-[5-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-indole-1-carbonyl]-phenyl}-carbamic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / N-bromosuccinimide, azoisobutyronitrile / CCl₄ / 4 h / Heating

2: NaH / 1.) DMF, 5 min, 2.) DMF, 2.5 h

3: 100 percent / 2 N aq. NaOH / methanol / 18 h / 60 °C

4: 30 percent / NaH / dimethylformamide / 16 h

With sodium hydroxide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydride; In methanol; tetrachloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00078a013