methyl 5-cyano-2-(2-{3-[(5-chloro-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl}ethenyl)benzoate

Base Information

• Chemical Name: methyl 5-cyano-2-(2-{3-[(5-chloro-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl}ethenyl)benzoate
• CAS No.: 668262-61-1
• Molecular Formula: C₂₅H₁₉ClN₂O₄S
• Molecular Weight: 478.956
• Mol file: 668262-61-1.mol

Synonyms:methyl 5-cyano-2-(2-{3-[(5-chloro-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl}ethenyl)benzoate

Chemical Property of methyl 5-cyano-2-(2-{3-[(5-chloro-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl}ethenyl)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 5-cyano-2-(2-{3-[(5-chloro-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl}ethenyl)benzoate

There total 6 articles about methyl 5-cyano-2-(2-{3-[(5-chloro-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl}ethenyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

C28H23NO2P(1+)*Br(1-) + 3-[(5-chloro-2,3-dihydro-1H-indol-1-yl)sulfonyl]benzaldehyde (668262-55-3) → methyl 5-cyano-2-(2-{3-[(5-chloro-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl}ethenyl)benzoate (668262-61-1)

Guidance literature:

With sodium hydride;

DOI:10.1016/j.bmcl.2007.02.055

Reference yield:

5-nitro-o-toluic acid (1975-52-6) → methyl 5-cyano-2-(2-{3-[(5-chloro-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl}ethenyl)benzoate (668262-61-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 93 percent / H+

2.1: 100 percent / H₂ / Raney Nickel

3.1: NaNO₂; aq. HCl

3.2: 42 percent / KCN / H₂O

4.1: 76 percent / NBS; AIBN

5.1: 82 percent / toluene

6.1: 73 percent / NaH

With hydrogenchloride; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); hydrogen; hydrogen cation; sodium hydride; sodium nitrite; nickel; In toluene;

DOI:10.1016/j.bmcl.2007.02.055

Reference yield:

methyl 2-methyl-5-nitrobenzoate (77324-87-9) → methyl 5-cyano-2-(2-{3-[(5-chloro-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl}ethenyl)benzoate (668262-61-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 100 percent / H₂ / Raney Nickel

2.1: NaNO₂; aq. HCl

2.2: 42 percent / KCN / H₂O

3.1: 76 percent / NBS; AIBN

4.1: 82 percent / toluene

5.1: 73 percent / NaH

With hydrogenchloride; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); hydrogen; sodium hydride; sodium nitrite; nickel; In toluene;

DOI:10.1016/j.bmcl.2007.02.055

upstream raw materials:

3-[(5-chloro-2,3-dihydro-1H-indol-1-yl)sulfonyl]benzaldehyde

5-nitro-o-toluic acid

5-cyano-2-methylbenzoic acid methyl ester

methyl 2-methyl-5-nitrobenzoate