5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl-4-methylbenzenesulfonate

Base Information

• Chemical Name: 5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl-4-methylbenzenesulfonate
• CAS No.: 1104802-77-8
• Molecular Formula: C₂₂H₁₆O₇S
• Molecular Weight: 424.431
• Mol file: 1104802-77-8.mol

Synonyms:5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl-4-methylbenzenesulfonate

Chemical Property of 5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl-4-methylbenzenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl-4-methylbenzenesulfonate

There total 5 articles about 5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl-4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-(5-acetoxy-4-oxo-7-(tosyloxy)-4H-chromen-2-yl)phenyl acetate (1610737-85-3) → 5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl-4-methylbenzenesulfonate (1104802-77-8)

Guidance literature:

With ammonia; In methanol; at 20 ℃; for 2h;

DOI:10.1016/j.bmc.2014.04.016

Reference yield: 88.0%

4'-O-methoxymethyl-7-O-tosylapigenin (1104802-64-3) → 5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl-4-methylbenzenesulfonate (1104802-77-8)

Guidance literature:

With methanol; acetyl chloride; In chloroform; at 20 ℃;

DOI:10.3987/COM-08-S(N)79

Reference yield:

5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one (520-36-5) → 5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl-4-methylbenzenesulfonate (1104802-77-8)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine / 6 h / 70 °C

2: thiophenol; 1H-imidazole / 1-methyl-pyrrolidin-2-one / 2 h / 0 - 20 °C

3: triethylamine / tetrahydrofuran / 8 h / 20 °C

4: ammonia / methanol / 2 h / 20 °C

With pyridine; 1H-imidazole; ammonia; thiophenol; triethylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol;

DOI:10.1016/j.bmc.2014.04.016

upstream raw materials:

4'-O-methoxymethyl-7-O-tosylapigenin

5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

apigenin triacetate

4-(5-acetoxy-7-hydroxy-4-oxo-4H-chromen-2-yl)phenylacetate

Downstream raw materials:

5-hydroxy-2-(4-hydroxyphenyl)-7-morpholino-4H-chromen-4-one

5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-4-oxo-4Hchromen-7-yl4-methylbenzenesulfonate

5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-7-morpholino-4H-chromen-4-one