ethyl 4-{3-[(2-methylacryloyl)amino]phenyl}-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate

Base Information

Chemical Name:ethyl 4-{3-[(2-methylacryloyl)amino]phenyl}-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate
CAS No.:1443235-95-7
Molecular Formula:C₁₉H₁₈N₄O₃
Molecular Weight:350.377
Hs Code.:

Synonyms:ethyl 4-{3-[(2-methylacryloyl)amino]phenyl}-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate

Suppliers and Price of ethyl 4-{3-[(2-methylacryloyl)amino]phenyl}-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
JAK3-IN-2 >98%
1 g
$ 2200.00

DC Chemicals
JAK3-IN-2 >98%
250 mg
$ 1100.00

ChemScene
JAK3-IN-6 98.07%
50mg
$ 465.00

ChemScene
JAK3-IN-6 98.07%
10mg
$ 155.00

ChemScene
JAK3-IN-6 98.07%
5mg
$ 90.00

Total 17 raw suppliers

Chemical Property of ethyl 4-{3-[(2-methylacryloyl)amino]phenyl}-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate

Chemical Property:

Density:1.302±0.06 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

JAK3-IN-2 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl 4-{3-[(2-methylacryloyl)amino]phenyl}-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate

There total 5 articles about ethyl 4-{3-[(2-methylacryloyl)amino]phenyl}-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1443234-84-1
ethyl 4-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate

: 920-46-7,26937-45-1
Methacryloyl chloride

: 1443235-95-7
ethyl 4-{3-[(2-methylacryloyl)amino]phenyl}-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 15 - 25 ℃; for 1h; Inert atmosphere;

Reference yield:

: 22276-95-5
5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

: 1443235-95-7
ethyl 4-{3-[(2-methylacryloyl)amino]phenyl}-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 3.5 h / -78 °C / Inert atmosphere

1.2: 14.5 h / -78 - 30 °C / Inert atmosphere

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / N,N-dimethyl-formamide / 1.5 h / 115 °C / Inert atmosphere

3.1: ; hydrogen / dichloromethane; methanol

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 15 - 25 °C / Inert atmosphere

With n-butyllithium; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1443237-43-1
ethyl 4-(3-nitrophenyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate

: 1443235-95-7
ethyl 4-{3-[(2-methylacryloyl)amino]phenyl}-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: ; hydrogen / dichloromethane; methanol

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 15 - 25 °C / Inert atmosphere

With hydrogen; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane;