(S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methyl-2-(1-(1-methyl-1H-indazol-5-yl)-2-oxo-1,2-dihydropyridin-3-yl)benzo[d]thiazol-6-3H)ethylpivalate

Base Information

Chemical Name:(S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methyl-2-(1-(1-methyl-1H-indazol-5-yl)-2-oxo-1,2-dihydropyridin-3-yl)benzo[d]thiazol-6-3H)ethylpivalate
CAS No.:1471257-24-5
Molecular Formula:C₃₈H₃₉ClN₄O₄S
Molecular Weight:683.271
Hs Code.:

Synonyms:(S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methyl-2-(1-(1-methyl-1H-indazol-5-yl)-2-oxo-1,2-dihydropyridin-3-yl)benzo[d]thiazol-6-3H)ethylpivalate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methyl-2-(1-(1-methyl-1H-indazol-5-yl)-2-oxo-1,2-dihydropyridin-3-yl)benzo[d]thiazol-6-3H)ethylpivalate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methyl-2-(1-(1-methyl-1H-indazol-5-yl)-2-oxo-1,2-dihydropyridin-3-yl)benzo[d]thiazol-6-3H)ethylpivalate

There total 12 articles about (S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methyl-2-(1-(1-methyl-1H-indazol-5-yl)-2-oxo-1,2-dihydropyridin-3-yl)benzo[d]thiazol-6-3H)ethylpivalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1470311-08-0
(S)-2-(2-bromo-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyethyl pivalate

: 1471257-23-4
1-(1-methyl-1H-indazol-5-yl)-2-oxo-1,2-dihydropyridin-3-ylboronic acid

: 1471257-24-5
(S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methyl-2-(1-(1-methyl-1H-indazol-5-yl)-2-oxo-1,2-dihydropyridin-3-yl)benzo[d]thiazol-6-3H)ethylpivalate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; ethanol; at 100 ℃; for 1h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 4186-49-6
2-bromo-6-methyl-4-nitrophenol

: 1471257-24-5
(S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methyl-2-(1-(1-methyl-1H-indazol-5-yl)-2-oxo-1,2-dihydropyridin-3-yl)benzo[d]thiazol-6-3H)ethylpivalate

Guidance literature:: Multi-step reaction with 10 steps

1.1: triethylamine / dichloromethane / 0.33 h / -70 °C

2.1: lithium chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 3 h / 70 °C / Inert atmosphere

2.2: 0.17 h / 70 °C

3.1: methanesulfonamide; hydroquinine 1,4-phthalazinediyl diether / water; tert-butyl alcohol / 72 h / 0 °C

4.1: pyridine / dichloromethane / 5 h / 0 - 20 °C

5.1: perchloric acid / 1.5 h / 0 - 20 °C

6.1: platinum on activated charcoal; hydrogen / ethanol / 3 h / 20 °C

7.1: acetic acid / 0.5 h / 20 °C

7.2: 2 h / 20 °C

8.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 3 h / 110 °C / Microwave irradiation

9.1: copper(ll) bromide; tert.-butylnitrite / acetonitrile; water / 1 h / 23 °C

10.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; ethanol / 1 h / 100 °C / Inert atmosphere; Microwave irradiation

With pyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butylnitrite; perchloric acid; methanesulfonamide; hydroquinine 1,4-phthalazinediyl diether; platinum on activated charcoal; hydrogen; potassium carbonate; acetic acid; triethylamine; lithium chloride; copper(ll) bromide; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;

Reference yield:

: 99-53-6
2-methyl-4-nitrophenol

: 1471257-24-5
(S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methyl-2-(1-(1-methyl-1H-indazol-5-yl)-2-oxo-1,2-dihydropyridin-3-yl)benzo[d]thiazol-6-3H)ethylpivalate

Guidance literature:: Multi-step reaction with 11 steps

1.1: bromine; acetic acid / 4 h / 20 °C

2.1: triethylamine / dichloromethane / 0.33 h / -70 °C

3.1: lithium chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 3 h / 70 °C / Inert atmosphere

3.2: 0.17 h / 70 °C

4.1: methanesulfonamide; hydroquinine 1,4-phthalazinediyl diether / water; tert-butyl alcohol / 72 h / 0 °C

5.1: pyridine / dichloromethane / 5 h / 0 - 20 °C

6.1: perchloric acid / 1.5 h / 0 - 20 °C

7.1: platinum on activated charcoal; hydrogen / ethanol / 3 h / 20 °C

8.1: acetic acid / 0.5 h / 20 °C

8.2: 2 h / 20 °C

9.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 3 h / 110 °C / Microwave irradiation

10.1: copper(ll) bromide; tert.-butylnitrite / acetonitrile; water / 1 h / 23 °C

11.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; ethanol / 1 h / 100 °C / Inert atmosphere; Microwave irradiation

With pyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butylnitrite; perchloric acid; methanesulfonamide; hydroquinine 1,4-phthalazinediyl diether; platinum on activated charcoal; hydrogen; bromine; potassium carbonate; acetic acid; triethylamine; lithium chloride; copper(ll) bromide; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;