(3R)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-[(N-({5-[(5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino]pyridin-3-yl}carbonyl)-N-methylglycyl)amino]propanoic acid ethyl ester monotrifluoroacetate

Base Information

Chemical Name:(3R)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-[(N-({5-[(5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino]pyridin-3-yl}carbonyl)-N-methylglycyl)amino]propanoic acid ethyl ester monotrifluoroacetate
CAS No.:726190-65-4
Molecular Formula:C₂HF₃O₂*C₂₄H₂₈BrClN₆O₆
Molecular Weight:725.904
Hs Code.:

(3R)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-[(N-({5-[(5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino]pyridin-3-yl}carbonyl)-N-methylglycyl)amino]propanoic acid ethyl ester monotrifluoroacetate

Synonyms:(3R)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-[(N-({5-[(5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino]pyridin-3-yl}carbonyl)-N-methylglycyl)amino]propanoic acid ethyl ester monotrifluoroacetate

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Chemical Property of (3R)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-[(N-({5-[(5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino]pyridin-3-yl}carbonyl)-N-methylglycyl)amino]propanoic acid ethyl ester monotrifluoroacetate

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Technology Process of (3R)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-[(N-({5-[(5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino]pyridin-3-yl}carbonyl)-N-methylglycyl)amino]propanoic acid ethyl ester monotrifluoroacetate

There total 1 articles about (3R)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-[(N-({5-[(5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino]pyridin-3-yl}carbonyl)-N-methylglycyl)amino]propanoic acid ethyl ester monotrifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 247102-01-8
5-N-(5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)-5-amino-nicotinic acid

: C₁₄H₁₈BrClN₂O₄*ClH

: 726190-65-4
(3R)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-[(N-({5-[(5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino]pyridin-3-yl}carbonyl)-N-methylglycyl)amino]propanoic acid ethyl ester monotrifluoroacetate

Guidance literature:: 5-N-(5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)-5-amino-nicotinic acid; With 4-methyl-morpholine; isobutyl chloroformate; In ISOPROPYLAMIDE; at 0 ℃; for 0.333333h;

C₁₄H₁₈BrClN₂O₄*ClH; In ISOPROPYLAMIDE; at 0 - 20 ℃;

Reference yield:

: 726190-65-4
(3R)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-[(N-({5-[(5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino]pyridin-3-yl}carbonyl)-N-methylglycyl)amino]propanoic acid ethyl ester monotrifluoroacetate

: 76-05-1
trifluoroacetic acid

: 726189-22-6
(3R)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-[(N-({5-[(5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino]pyridin-3-yl}carbonyl)-N-methylglycyl)amino]propanoic acid monotrifluoroacetate

Guidance literature:: (3R)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-[(N-({5-[(5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino]pyridin-3-yl}carbonyl)-N-methylglycyl)amino]propanoic acid ethyl ester monotrifluoroacetate; With sodium hydroxide; water; at 20 ℃; for 2h;

trifluoroacetic acid; pH=4;