methyl 3-O-(2-hydroxyethyl)-4-azido-2-O-benzyl-4,6-dideoxy-α-D-glucopyranoside

Base Information

Chemical Name:methyl 3-O-(2-hydroxyethyl)-4-azido-2-O-benzyl-4,6-dideoxy-α-D-glucopyranoside
CAS No.:502621-12-7
Molecular Formula:C₁₆H₂₃N₃O₅
Molecular Weight:337.376
Hs Code.:

Synonyms:methyl 3-O-(2-hydroxyethyl)-4-azido-2-O-benzyl-4,6-dideoxy-α-D-glucopyranoside

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Chemical Property of methyl 3-O-(2-hydroxyethyl)-4-azido-2-O-benzyl-4,6-dideoxy-α-D-glucopyranoside

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Technology Process of methyl 3-O-(2-hydroxyethyl)-4-azido-2-O-benzyl-4,6-dideoxy-α-D-glucopyranoside

There total 8 articles about methyl 3-O-(2-hydroxyethyl)-4-azido-2-O-benzyl-4,6-dideoxy-α-D-glucopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 502621-11-6
methyl 3-O-allyl-4-azido-2-O-benzyl-4,6-dideoxy-α-D-glucopyranoside

: 502621-12-7
methyl 3-O-(2-hydroxyethyl)-4-azido-2-O-benzyl-4,6-dideoxy-α-D-glucopyranoside

Guidance literature:: methyl 3-O-allyl-4-azido-2-O-benzyl-4,6-dideoxy-α-D-glucopyranoside; With ozone; In dichloromethane;

With sodium tetrahydroborate; In methanol; dichloromethane; at 0 ℃; Further stages.;
DOI:10.1021/ol027288c

Reference yield:

: 58341-57-4
Methyl 3-O-allyl-2-O-benzyl-α-D-glucopyranoside

: 502621-12-7
methyl 3-O-(2-hydroxyethyl)-4-azido-2-O-benzyl-4,6-dideoxy-α-D-glucopyranoside

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridine / 0 - 20 °C

2.1: LiAlH₄ / tetrahydrofuran / 5 h / Heating

3.1: (COCl)2; DMSO; DIPEA / CH₂Cl₂ / -78 - 0 °C

4.1: NaBH₄ / methanol / 4 h / 0 °C

5.1: pyridine / CH₂Cl₂ / 0.5 h / 0 °C

6.1: NaN₃ / dimethylformamide

7.1: O₃ / CH₂Cl₂

7.2: 70 percent / NaBH₄ / methanol; CH₂Cl₂ / 0 °C

With pyridine; sodium tetrahydroborate; lithium aluminium tetrahydride; sodium azide; oxalyl dichloride; ozone; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; pyridine; methanol; dichloromethane; N,N-dimethyl-formamide; 3.1: Swern oxidation;
DOI:10.1021/ol027288c

Reference yield:

: 142967-65-5
Methyl 3-O-allyl-2-O-benzyl-6-O-p-tolylsulfonyl-α-D-glucopyranoside

: 502621-12-7
methyl 3-O-(2-hydroxyethyl)-4-azido-2-O-benzyl-4,6-dideoxy-α-D-glucopyranoside

Guidance literature:: Multi-step reaction with 6 steps

1.1: LiAlH₄ / tetrahydrofuran / 5 h / Heating

2.1: (COCl)2; DMSO; DIPEA / CH₂Cl₂ / -78 - 0 °C

3.1: NaBH₄ / methanol / 4 h / 0 °C

4.1: pyridine / CH₂Cl₂ / 0.5 h / 0 °C

5.1: NaN₃ / dimethylformamide

6.1: O₃ / CH₂Cl₂

6.2: 70 percent / NaBH₄ / methanol; CH₂Cl₂ / 0 °C

With pyridine; sodium tetrahydroborate; lithium aluminium tetrahydride; sodium azide; oxalyl dichloride; ozone; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 2.1: Swern oxidation;
DOI:10.1021/ol027288c