2-((2R,3S,6R)-3-Benzyloxymethoxy-6-methyl-tetrahydro-pyran-2-yl)-ethanol

Base Information

Chemical Name:2-((2R,3S,6R)-3-Benzyloxymethoxy-6-methyl-tetrahydro-pyran-2-yl)-ethanol
CAS No.:152901-66-1
Molecular Formula:C₁₆H₂₄O₄
Molecular Weight:280.364
Hs Code.:

Synonyms:2-((2R,3S,6R)-3-Benzyloxymethoxy-6-methyl-tetrahydro-pyran-2-yl)-ethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-((2R,3S,6R)-3-Benzyloxymethoxy-6-methyl-tetrahydro-pyran-2-yl)-ethanol

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Technology Process of 2-((2R,3S,6R)-3-Benzyloxymethoxy-6-methyl-tetrahydro-pyran-2-yl)-ethanol

There total 7 articles about 2-((2R,3S,6R)-3-Benzyloxymethoxy-6-methyl-tetrahydro-pyran-2-yl)-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 152901-65-0
((2R,3S,6R)-3-Benzyloxymethoxy-6-methyl-tetrahydro-pyran-2-yl)-acetic acid methyl ester

: 152901-66-1
2-((2R,3S,6R)-3-Benzyloxymethoxy-6-methyl-tetrahydro-pyran-2-yl)-ethanol

Guidance literature:: With lithium aluminium tetrahydride;
DOI:10.1016/S0040-4039(00)73848-2

Reference yield:

: 1888-89-7,74892-53-8,131722-62-8,74892-51-6
(2S,5S)-1,5-hexadiene diepoxide

: 152901-66-1
2-((2R,3S,6R)-3-Benzyloxymethoxy-6-methyl-tetrahydro-pyran-2-yl)-ethanol

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) Vitride, 2.) DMAP / 1.) THF

2: 1.) LDA / 1.) THF

3: 1.) mCPBA, 2.) pyridine / 1.) CH₂Cl₂, -30 deg C, 1 h, 2.) toluene, reflux

4: i-PrNEt₂ / CH₂Cl₂ / Heating

5: Bu₄NF / tetrahydrofuran / 2 h / Heating

6: K₂CO₃ / tetrahydrofuran / 12 h / Heating

7: 93 percent / LiAlH₄

With pyridine; dmap; lithium aluminium tetrahydride; N,N-diethyl-N-isopropylamine; tetrabutyl ammonium fluoride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; sodium bis(2-methoxyethoxy)aluminium dihydride; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4039(00)73848-2

Reference yield:

: 152901-64-9
(E)-(4S,7R)-4-Benzyloxymethoxy-7-hydroxy-oct-2-enoic acid methyl ester

: 152901-66-1
2-((2R,3S,6R)-3-Benzyloxymethoxy-6-methyl-tetrahydro-pyran-2-yl)-ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: K₂CO₃ / tetrahydrofuran / 12 h / Heating

2: 93 percent / LiAlH₄

With lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran;
DOI:10.1016/S0040-4039(00)73848-2