C₂₂H₂₃ClFN₅O

Base Information

Chemical Name:C₂₂H₂₃ClFN₅O
CAS No.:1350641-32-5
Molecular Formula:C₂₂H₂₃ClFN₅O
Molecular Weight:427.909
Hs Code.:

C<sub>22</sub>H<sub>23</sub>ClFN<sub>5</sub>O

Synonyms:C₂₂H₂₃ClFN₅O

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Chemical Property of C₂₂H₂₃ClFN₅O

Chemical Property:

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Technology Process of C₂₂H₂₃ClFN₅O

There total 3 articles about C₂₂H₂₃ClFN₅O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 367-21-5
3-chloro-4-fluorophenylamine

: 1355676-73-1
C₁₆H₁₉ClN₄O

: 1350641-32-5
C₂₂H₂₃ClFN₅O

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 85 ℃; Inert atmosphere;
DOI:10.1016/j.bmcl.2011.09.033

Reference yield:

: 110-89-4
piperidine

: 1350641-32-5
C₂₂H₂₃ClFN₅O

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / 0.5 h / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine / butan-1-ol

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 85 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate; triethylamine; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; butan-1-ol; 3: Buchwald-Hartwig coupling;
DOI:10.1016/j.bmcl.2011.09.033

Reference yield:

: 213201-98-0
2,4-dichloro-6-(piperidin-1-yl)pyrimidine

: 1350641-32-5
C₂₂H₂₃ClFN₅O

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / butan-1-ol

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 85 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; butan-1-ol; 2: Buchwald-Hartwig coupling;
DOI:10.1016/j.bmcl.2011.09.033