(S)-(-)-<2-(Azidomethyl)-4-(4-bromophenyl)butoxy>(1,1-dimethylethyl)dimethylsilane

Base Information

Chemical Name:(S)-(-)-<2-(Azidomethyl)-4-(4-bromophenyl)butoxy>(1,1-dimethylethyl)dimethylsilane
CAS No.:127633-56-1
Molecular Formula:C₁₇H₂₈BrN₃OSi
Molecular Weight:398.418
Hs Code.:

Synonyms:(S)-(-)-<2-(Azidomethyl)-4-(4-bromophenyl)butoxy>(1,1-dimethylethyl)dimethylsilane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-(-)-<2-(Azidomethyl)-4-(4-bromophenyl)butoxy>(1,1-dimethylethyl)dimethylsilane

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Technology Process of (S)-(-)-<2-(Azidomethyl)-4-(4-bromophenyl)butoxy>(1,1-dimethylethyl)dimethylsilane

There total 7 articles about (S)-(-)-<2-(Azidomethyl)-4-(4-bromophenyl)butoxy>(1,1-dimethylethyl)dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 127633-61-8
2-<2-(4-Bromophenyl)ethyl>-1,3-propanediol diacetate

: 127633-56-1
(S)-(-)-<2-(Azidomethyl)-4-(4-bromophenyl)butoxy>(1,1-dimethylethyl)dimethylsilane

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(01)93875-4

Reference yield:

: (RS)-4-Bromo-β-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>benzenebutanol methanesulfonate

: 127633-56-1
(S)-(-)-<2-(Azidomethyl)-4-(4-bromophenyl)butoxy>(1,1-dimethylethyl)dimethylsilane

: (R)-<2-(Azidomethyl)-4-(4-bromophenyl)butoxy>(1,1-dimethylethyl)dimethylsilane

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 80 ℃; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1021/jo00102a031

Reference yield:

: 4654-39-1
4-bromophenethanol

: 127633-56-1
(S)-(-)-<2-(Azidomethyl)-4-(4-bromophenyl)butoxy>(1,1-dimethylethyl)dimethylsilane

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N

2: 90 percent / NaH

3: 75 percent / LiAlH₄ / diethyl ether

4: with porcine pancreatic lipase (PPL, Sigma type II, no. 3126)

5: 88 percent / NaN₃ / dimethylformamide

With lithium aluminium tetrahydride; sodium azide; sodium hydride; triethylamine; In diethyl ether; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(01)93875-4