(Z)-2-(1-iodo-1-phenyl)methylenecyclooctanone

Base Information

• Chemical Name: (Z)-2-(1-iodo-1-phenyl)methylenecyclooctanone
• CAS No.: 810676-41-6
• Molecular Formula: C₁₅H₁₇IO
• Molecular Weight: 340.204
• Mol file: 810676-41-6.mol

Synonyms:(Z)-2-(1-iodo-1-phenyl)methylenecyclooctanone

Chemical Property of (Z)-2-(1-iodo-1-phenyl)methylenecyclooctanone

Chemical Property:

Purity/Quality:

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• Pictogram(s):  
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MSDS Files:

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Technology Process of (Z)-2-(1-iodo-1-phenyl)methylenecyclooctanone

There total 2 articles about (Z)-2-(1-iodo-1-phenyl)methylenecyclooctanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

1-hydroxy-1-(2-phenylethynyl)cycloheptane (72946-37-3) → (Z)-2-(1-iodo-1-phenyl)methylenecyclooctanone (810676-41-6)

Guidance literature:

With poly[styrene(iodosodiacetate)]; iodine; In dichloromethane; at 20 ℃; for 11h;

DOI:10.1055/s-2004-831214

Reference yield:

phenylacetylene (536-74-3) → (Z)-2-(1-iodo-1-phenyl)methylenecyclooctanone (810676-41-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Mg; I₂; EtBr / tetrahydrofuran / 1 h / 20 °C

1.2: tetrahydrofuran / 2 h / 0 °C

2.1: 67 percent / poly[styrene(iodosodiacetate)]; I₂ / CH₂Cl₂ / 11 h / 20 °C

With poly[styrene(iodosodiacetate)]; iodine; ethidium Bromide; magnesium; In tetrahydrofuran; dichloromethane;

DOI:10.1055/s-2004-831214

Reference yield: 92.0%

phenylacetylene (536-74-3) + (Z)-2-(1-iodo-1-phenyl)methylenecyclooctanone (810676-41-6) → (Z)-2-(1-phenyl-1-phenylethynyl)methylenecyclooctanone

Guidance literature:

With copper(l) iodide; potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; In acetonitrile; at 60 ℃; for 12h;

DOI:10.1055/s-2004-831214

upstream raw materials:

1-hydroxy-1-(2-phenylethynyl)cycloheptane

phenylacetylene