6-(2-methoxypyrimidin-4-yl)-2-phenoxymethyl-6H-imidazo[1,2-c]pyrimidin-5-one

Base Information

Chemical Name:6-(2-methoxypyrimidin-4-yl)-2-phenoxymethyl-6H-imidazo[1,2-c]pyrimidin-5-one
CAS No.:1400633-70-6
Molecular Formula:C₁₈H₁₅N₅O₃
Molecular Weight:349.349
Hs Code.:

Synonyms:6-(2-methoxypyrimidin-4-yl)-2-phenoxymethyl-6H-imidazo[1,2-c]pyrimidin-5-one

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Chemical Property of 6-(2-methoxypyrimidin-4-yl)-2-phenoxymethyl-6H-imidazo[1,2-c]pyrimidin-5-one

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Technology Process of 6-(2-methoxypyrimidin-4-yl)-2-phenoxymethyl-6H-imidazo[1,2-c]pyrimidin-5-one

There total 4 articles about 6-(2-methoxypyrimidin-4-yl)-2-phenoxymethyl-6H-imidazo[1,2-c]pyrimidin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1400633-46-6
2-phenoxymethyl-6H-imidazo[1,2-c]pyrimidin-5-one

: 51421-99-9
4-chloro-2-methoxy-pyrimidine

: 1400633-70-6
6-(2-methoxypyrimidin-4-yl)-2-phenoxymethyl-6H-imidazo[1,2-c]pyrimidin-5-one

Guidance literature:: With caesium carbonate; palladium diacetate; XPhos; In 1,4-dioxane; at 100 - 140 ℃; for 72h; Inert atmosphere; Sealed tube; Microwave irradiation;

Reference yield:

: 1059191-49-9
7-chloro-2-chloromethyl-5-methylsulfanylimidazo[1,2-c]pyrimidine

: 1400633-70-6
6-(2-methoxypyrimidin-4-yl)-2-phenoxymethyl-6H-imidazo[1,2-c]pyrimidin-5-one

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 18 h / 50 °C

2: lithium hydroxide / water; tetrahydrofuran / 4 h / 50 °C

3: triethylamine; hydrogen / palladium(II) hydroxide / ethyl acetate; methanol / 80 h / 50 °C / 2327.23 Torr

4: caesium carbonate / palladium diacetate; XPhos / 1,4-dioxane / 72 h / 100 - 140 °C / Inert atmosphere; Sealed tube; Microwave irradiation

With hydrogen; potassium carbonate; caesium carbonate; triethylamine; lithium hydroxide; palladium diacetate; palladium(II) hydroxide; XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; water; ethyl acetate; acetonitrile;

Reference yield:

: 1400633-90-0
7-chloro-5-methylsulfanyl-2-phenoxymethylimidazo[1,2-c]pyrimidine

: 1400633-70-6
6-(2-methoxypyrimidin-4-yl)-2-phenoxymethyl-6H-imidazo[1,2-c]pyrimidin-5-one

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide / water; tetrahydrofuran / 4 h / 50 °C

2: triethylamine; hydrogen / palladium(II) hydroxide / ethyl acetate; methanol / 80 h / 50 °C / 2327.23 Torr

3: caesium carbonate / palladium diacetate; XPhos / 1,4-dioxane / 72 h / 100 - 140 °C / Inert atmosphere; Sealed tube; Microwave irradiation

With hydrogen; caesium carbonate; triethylamine; lithium hydroxide; palladium diacetate; palladium(II) hydroxide; XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; water; ethyl acetate;