ethyl cyano[1-(3-thienyl)cyclohexyl]acetate

Base Information

• Chemical Name: ethyl cyano[1-(3-thienyl)cyclohexyl]acetate
• CAS No.: 78501-99-2
• Molecular Formula: C₁₅H₁₉NO₂S
• Molecular Weight: 277.387
• Mol file: 78501-99-2.mol

Synonyms:2-<1-(3-Thienyl)-cyclohexyl>-cyanessigsaeureethylester

Chemical Property of ethyl cyano[1-(3-thienyl)cyclohexyl]acetate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of ethyl cyano[1-(3-thienyl)cyclohexyl]acetate

There total 1 articles about ethyl cyano[1-(3-thienyl)cyclohexyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Bromothiophene (872-31-1) + ethyl 2-cyano-2-cyclohexylideneacetate (6802-76-2) → 2-<1-(3-Thienyl)-cyclohexyl>-cyanessigsaeureethylester (78501-99-2)

Guidance literature:

With magnesium; ethylene dibromide; Yield given. Multistep reaction; 1.) ether; 2.) ether, reflux, 1 h;

Reference yield: 89.1%

2-<1-(3-Thienyl)-cyclohexyl>-cyanessigsaeureethylester (78501-99-2) → <1-(3-Thienyl)-cyclohexyl>-essigsaeure (78502-02-0)

Guidance literature:

With potassium hydroxide; In water; ethylene glycol; for 15h; Heating;

Reference yield:

2-<1-(3-Thienyl)-cyclohexyl>-cyanessigsaeureethylester (78501-99-2) → <1-(2,5-Dichlor-3-thienyl)-cyclohexyl>-essigsaeure (78502-03-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 89.1 percent / KOH / ethane-1,2-diol; H₂O / 15 h / Heating

2: 89.7 percent / SO₂Cl₂ / CHCl₃ / 4 h / Heating

With potassium hydroxide; sulfuryl dichloride; In chloroform; water; ethylene glycol;

upstream raw materials:

3-Bromothiophene

ethyl 2-cyano-2-cyclohexylideneacetate

Downstream raw materials:

<1-(3-Thienyl)-cyclohexyl>-essigsaeure

<1-(2,5-Dichlor-3-thienyl)-cyclohexyl>-essigsaeure

Refernces