N,N-dimethyl-3-[1-methyl-3-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]aniline

Base Information

Chemical Name:N,N-dimethyl-3-[1-methyl-3-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]aniline
CAS No.:1279823-96-9
Molecular Formula:C₂₂H₁₉F₃N₄
Molecular Weight:396.415
Hs Code.:

Synonyms:N,N-dimethyl-3-[1-methyl-3-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]aniline

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Chemical Property of N,N-dimethyl-3-[1-methyl-3-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]aniline

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Technology Process of N,N-dimethyl-3-[1-methyl-3-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]aniline

There total 4 articles about N,N-dimethyl-3-[1-methyl-3-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 178752-79-9
3-(N,N-dimethylamino)phenylboronic acid

: 1312949-16-8
6-bromo-1-methyl-3-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine

: 1279823-96-9
N,N-dimethyl-3-[1-methyl-3-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]aniline

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tripotassium phosphate dihydrate; In 1,2-dimethoxyethane; water; at 150 ℃; for 0.25h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 94835-71-9
3-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-6-ol

: 1279823-96-9
N,N-dimethyl-3-[1-methyl-3-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]aniline

Guidance literature:: Multi-step reaction with 3 steps

1: phosphorus(V) oxybromide / toluene / 18 h / 90 °C

2: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

3: tripotassium phosphate dihydrate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 0.25 h / 150 °C / Inert atmosphere; Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tripotassium phosphate dihydrate; potassium carbonate; phosphorus(V) oxybromide; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 827-41-8
3-phenylpyrazol-5-amine

: 1279823-96-9
N,N-dimethyl-3-[1-methyl-3-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]aniline

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid; water / 18 h / 90 °C

2: phosphorus(V) oxybromide / toluene / 18 h / 90 °C

3: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

4: tripotassium phosphate dihydrate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 0.25 h / 150 °C / Inert atmosphere; Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tripotassium phosphate dihydrate; potassium carbonate; phosphorus(V) oxybromide; In 1,2-dimethoxyethane; water; acetic acid; N,N-dimethyl-formamide; toluene;