(1R,2R,5R)-5-Methyl-2-(1-methyl-1-naphthalen-2-yl-ethyl)-cyclohexanecarbaldehyde

Base Information

Chemical Name:(1R,2R,5R)-5-Methyl-2-(1-methyl-1-naphthalen-2-yl-ethyl)-cyclohexanecarbaldehyde
CAS No.:183434-77-7
Molecular Formula:C₂₁H₂₆O
Molecular Weight:294.437
Hs Code.:

Synonyms:(1R,2R,5R)-5-Methyl-2-(1-methyl-1-naphthalen-2-yl-ethyl)-cyclohexanecarbaldehyde

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Chemical Property of (1R,2R,5R)-5-Methyl-2-(1-methyl-1-naphthalen-2-yl-ethyl)-cyclohexanecarbaldehyde

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Technology Process of (1R,2R,5R)-5-Methyl-2-(1-methyl-1-naphthalen-2-yl-ethyl)-cyclohexanecarbaldehyde

There total 7 articles about (1R,2R,5R)-5-Methyl-2-(1-methyl-1-naphthalen-2-yl-ethyl)-cyclohexanecarbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 183434-76-6
[(1R,2R,5R)-5-Methyl-2-(1-methyl-1-naphthalen-2-yl-ethyl)-cyclohexyl]-methanol

: 183434-77-7
(1R,2R,5R)-5-Methyl-2-(1-methyl-1-naphthalen-2-yl-ethyl)-cyclohexanecarbaldehyde

Guidance literature:: With oxalyl dichloride; 4 A molecular sieve; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 0.25h;
DOI:10.1016/0040-4020(96)00744-2

Reference yield:

: 21473-01-8
2-naphthalenylmagnesium bromide

: 183434-77-7
(1R,2R,5R)-5-Methyl-2-(1-methyl-1-naphthalen-2-yl-ethyl)-cyclohexanecarbaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran

2: 1.) LDA / 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, 0 deg C, 1 h

3: 75 percent / Pd(OAc)2(Ph₃P)2 / dimethylformamide / 96 h

4: Mg, MeOH / 10 h

5: 96 percent / DIBAL / toluene; tetrahydrofuran / 2 h

6: 77 percent / (COCl)2, DMSO, molecular sieves 4A / CH₂Cl₂ / 0.25 h / -78 °C

With methanol; bis(triphenylphosphine) palladium (Il) acetate; oxalyl dichloride; 4 A molecular sieve; diisobutylaluminium hydride; magnesium; dimethyl sulfoxide; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/0040-4020(96)00744-2

Reference yield:

: 89-82-7,90449-51-7
pulegone

: 183434-77-7
(1R,2R,5R)-5-Methyl-2-(1-methyl-1-naphthalen-2-yl-ethyl)-cyclohexanecarbaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran

2: 1.) LDA / 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, 0 deg C, 1 h

3: 75 percent / Pd(OAc)2(Ph₃P)2 / dimethylformamide / 96 h

4: Mg, MeOH / 10 h

5: 96 percent / DIBAL / toluene; tetrahydrofuran / 2 h

6: 77 percent / (COCl)2, DMSO, molecular sieves 4A / CH₂Cl₂ / 0.25 h / -78 °C

With methanol; bis(triphenylphosphine) palladium (Il) acetate; oxalyl dichloride; 4 A molecular sieve; diisobutylaluminium hydride; magnesium; dimethyl sulfoxide; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/0040-4020(96)00744-2