1-(2-O-acetyl-3-deoxy-3-trifluoromethyl-5-O-benzoyl-β-D-ribofuranosyl)thymine

Base Information

Chemical Name:1-(2-O-acetyl-3-deoxy-3-trifluoromethyl-5-O-benzoyl-β-D-ribofuranosyl)thymine
CAS No.:272112-09-1
Molecular Formula:C₂₀H₁₉F₃N₂O₇
Molecular Weight:456.375
Hs Code.:

Synonyms:1-(2-O-acetyl-3-deoxy-3-trifluoromethyl-5-O-benzoyl-β-D-ribofuranosyl)thymine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(2-O-acetyl-3-deoxy-3-trifluoromethyl-5-O-benzoyl-β-D-ribofuranosyl)thymine

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Technology Process of 1-(2-O-acetyl-3-deoxy-3-trifluoromethyl-5-O-benzoyl-β-D-ribofuranosyl)thymine

There total 1 articles about 1-(2-O-acetyl-3-deoxy-3-trifluoromethyl-5-O-benzoyl-β-D-ribofuranosyl)thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.5%

: 65-71-4,28806-14-6,691841-57-3
thymin

: 272112-08-0
1,2-di-O-acetyl-3-deoxy-3-trifluoromethyl-5-O-benzoyl-β-D-ribofuranose

: 272112-09-1
1-(2-O-acetyl-3-deoxy-3-trifluoromethyl-5-O-benzoyl-β-D-ribofuranosyl)thymine

Guidance literature:: thymin; With chloro-trimethyl-silane; In benzene; at 20 ℃; for 15h;

1,2-di-O-acetyl-3-deoxy-3-trifluoromethyl-5-O-benzoyl-β-D-ribofuranose; With trimethylsilyl trifluoromethanesulfonate; In acetonitrile; at 20 ℃; for 20h;
DOI:10.1080/15257770008035023

Reference yield: 82.8%

: 272112-09-1
1-(2-O-acetyl-3-deoxy-3-trifluoromethyl-5-O-benzoyl-β-D-ribofuranosyl)thymine

: 272112-11-5
1-(3-deoxy-3-trifluoromethyl-5-O-benzoyl-β-D-ribofuranosyl)thymine

Guidance literature:: With pyridine; hydrazine hydrate; acetic acid; at 20 ℃; for 24h;
DOI:10.1080/15257770008035023

Reference yield:

: 272112-09-1
1-(2-O-acetyl-3-deoxy-3-trifluoromethyl-5-O-benzoyl-β-D-ribofuranosyl)thymine

: Benzoic acid (2S,3R,4R,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-phenoxythiocarbonyloxy-3-trifluoromethyl-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 82.8 percent / hydrazine monohydrate; AcOH; pyridine / 24 h / 20 °C

2: 4-DMAP / CH₂Cl₂ / 1 h / 20 °C

With pyridine; dmap; hydrazine hydrate; acetic acid; In dichloromethane; 1: Deacetylation / 2: Substitution;
DOI:10.1080/15257770008035023