2-[(2S,5S,6R)-6-((S)-3-((2R,4S,6S)-4-(tert-butyldiphenylsilanyloxy)-6-[2-(4-methoxybenzyloxy)ethyl]-tetrahydropyran-2-yl)-2-methoxypropyl)-5-methyltetrahydropyran-2-yl]-ethanol

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Chemical Name:2-[(2S,5S,6R)-6-((S)-3-((2R,4S,6S)-4-(tert-butyldiphenylsilanyloxy)-6-[2-(4-methoxybenzyloxy)ethyl]-tetrahydropyran-2-yl)-2-methoxypropyl)-5-methyltetrahydropyran-2-yl]-ethanol
CAS No.:617715-14-7
Molecular Formula:C₄₃H₆₂O₇Si
Molecular Weight:719.047
Hs Code.:

2-[(2S,5S,6R)-6-((S)-3-((2R,4S,6S)-4-(tert-butyldiphenylsilanyloxy)-6-[2-(4-methoxybenzyloxy)ethyl]-tetrahydropyran-2-yl)-2-methoxypropyl)-5-methyltetrahydropyran-2-yl]-ethanol

Synonyms:2-[(2S,5S,6R)-6-((S)-3-((2R,4S,6S)-4-(tert-butyldiphenylsilanyloxy)-6-[2-(4-methoxybenzyloxy)ethyl]-tetrahydropyran-2-yl)-2-methoxypropyl)-5-methyltetrahydropyran-2-yl]-ethanol

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Chemical Property of 2-[(2S,5S,6R)-6-((S)-3-((2R,4S,6S)-4-(tert-butyldiphenylsilanyloxy)-6-[2-(4-methoxybenzyloxy)ethyl]-tetrahydropyran-2-yl)-2-methoxypropyl)-5-methyltetrahydropyran-2-yl]-ethanol

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Technology Process of 2-[(2S,5S,6R)-6-((S)-3-((2R,4S,6S)-4-(tert-butyldiphenylsilanyloxy)-6-[2-(4-methoxybenzyloxy)ethyl]-tetrahydropyran-2-yl)-2-methoxypropyl)-5-methyltetrahydropyran-2-yl]-ethanol

There total 6 articles about 2-[(2S,5S,6R)-6-((S)-3-((2R,4S,6S)-4-(tert-butyldiphenylsilanyloxy)-6-[2-(4-methoxybenzyloxy)ethyl]-tetrahydropyran-2-yl)-2-methoxypropyl)-5-methyltetrahydropyran-2-yl]-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 617715-13-6
toluene-4-sulfonic acid (1S,2S,5S)-1-((S)-3-((2R,4S,6S)-4-(tert-butyldiphenylsilanyloxy)-6-[2-(4-methoxybenzyloxy)ethyl]-tetrahydropyran-2-yl)-2-methoxypropyl)-5,7-dihydroxy-2-methylheptyl ester

: 617715-14-7
2-[(2S,5S,6R)-6-((S)-3-((2R,4S,6S)-4-(tert-butyldiphenylsilanyloxy)-6-[2-(4-methoxybenzyloxy)ethyl]-tetrahydropyran-2-yl)-2-methoxypropyl)-5-methyltetrahydropyran-2-yl]-ethanol

Guidance literature:: With sodium hydride; In benzene; at 60 ℃; for 16h;
DOI:10.1002/anie.200351817

Reference yield:

: 617714-97-3
(2R,6S)-2-[(2S,5S,8S)-8,10-bis-(tert-butyldimethylsilanyloxy)-2-methoxy-5-methyl-4-oxodecyl]-6-[2-(4-methoxybenzyloxy)ethyl]-tetrahydropyran-4-one

: 617715-14-7
2-[(2S,5S,6R)-6-((S)-3-((2R,4S,6S)-4-(tert-butyldiphenylsilanyloxy)-6-[2-(4-methoxybenzyloxy)ethyl]-tetrahydropyran-2-yl)-2-methoxypropyl)-5-methyltetrahydropyran-2-yl]-ethanol

Guidance literature:: Multi-step reaction with 6 steps

1: 84 percent / lithium tri-sec-butylborohydride / tetrahydrofuran / 1.5 h / -78 °C

2: 73 percent / imidazole / dimethylformamide / 40 h

3: 95 percent / LiAlH₄; (-)-N-methylephedrine; N-ethylaniline / diethyl ether / 2 h / -78 °C

4: 100 percent / pyridine / CH₂Cl₂

5: 84 percent / HF*pyridine; pyridine / tetrahydrofuran

6: 73 percent / sodium hydride / benzene / 16 h / 60 °C

With pyridine; 1H-imidazole; lithium aluminium tetrahydride; (-)-N-methylephedrine; L-Selectride; sodium hydride; pyridine hydrogenfluoride; N-ethyl-N-phenylamine; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; benzene; 3: Terashima reduction;
DOI:10.1002/anie.200351817

Reference yield:

: 617715-10-3
(2S,5S,8S)-8,10-bis-(tert-butyldimethylsilanyloxy)-1-{(2S,4S,6S)-4-hydroxy-6-[2-(4-methoxybenzyloxy)ethyl]-tetrahydropyran-2-yl}-2-methoxy-5-methyldecan-4-one

: 617715-14-7
2-[(2S,5S,6R)-6-((S)-3-((2R,4S,6S)-4-(tert-butyldiphenylsilanyloxy)-6-[2-(4-methoxybenzyloxy)ethyl]-tetrahydropyran-2-yl)-2-methoxypropyl)-5-methyltetrahydropyran-2-yl]-ethanol

Guidance literature:: Multi-step reaction with 5 steps

1: 73 percent / imidazole / dimethylformamide / 40 h

2: 95 percent / LiAlH₄; (-)-N-methylephedrine; N-ethylaniline / diethyl ether / 2 h / -78 °C

3: 100 percent / pyridine / CH₂Cl₂

4: 84 percent / HF*pyridine; pyridine / tetrahydrofuran

5: 73 percent / sodium hydride / benzene / 16 h / 60 °C

With pyridine; 1H-imidazole; lithium aluminium tetrahydride; (-)-N-methylephedrine; sodium hydride; pyridine hydrogenfluoride; N-ethyl-N-phenylamine; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; benzene; 2: Terashima reduction;
DOI:10.1002/anie.200351817